this article will review the essential chemical structure of ida derivatives and their biokinetic characteristics as the hepatobiliary agents. the article also presents the procedures of synthesis, formulation and quality control of mebrofenin (brida) as a 99mtc-radiopharmaceuticai kit which is produced in radioisotope division of n.r.c. 99mtc-brida has extremely low renal excretion and hence g...

This article will review the essential chemical structure of IDA derivatives and their biokinetic characteristics as the hepatobiliary agents. The article also presents the procedures of Synthesis, formulation and Quality control of mebrofenin (BRIDA) as a 99mTc-Radiopharmaceuticai kit which is produced in Radioisotope Division of N.R.C. 99mTc-BRiDA has extremely low renal excretion and h...

Technetium is an element that is artificially produced and all its isotopes are radioactive. Several investigations have been performed on the subject of the production of Tc radioisotopes using cyclotrons. Among these radioisotopes, 99mTc with a half-life of 6.02 h and gamma-ray spectrum with an energy peak at 140.5 keV has a vast application in nuclear medicine. More than 85% of administered ...

AIM Hepatobiliary scintigraphy is an integral part in the diagnostic work-up of the neonatal cholestasis syndrome. However, less than optimal specificity is its major disadvantage. Differentiation between biliary atresia and neonatal hepatitis is nearly impossible in some cases with poor hepatocellular function. 99mTc sestamibi (MIBI) is a cationic lipophilic agent which is a substrate of P-gly...

introduction: early differentiation of biliary atresia from neonatal hepatitis is of utmost importance, since on time surgery of biliary atresia significantly improves the outcome. hepatobiliary scintigraphy is an integral part of diagnosis work-up of these patients; however its specificity for diagnosis of biliary atresia is suboptimal. in this study we evaluated the value of ursodeoxycholic a...

http://dx.doi.org/10.1016/j.eswa.2014.01.019 0957-4174/ 2014 Elsevier Ltd. All rights reserved. ⇑ Corresponding author. Address: School of Economics and Management, Free University of Bolzano, Piazzetta dell’Università, 39031 Brunico (BZ), Italy. Tel.: +39 0471 013293; fax: +39 0471 013009. E-mail addresses: [email protected] (J.G. Brida), [email protected] (M. Disegna), Raffaele....

OBJECTIVES To use (99m)Tc sulfur colloid ((99m)Tc-SC) and (99m)Tc mebrofenin ((99m)Tc-BrIDA) to study liver function in normal and diabetic rats. MATERIALS AND METHODS Radionuclide imaging was performed on 2 groups of rats, using (99m)Tc-SC for one group and (99m)Tc-BrIDA for the other (20 rats per group) before and after induction of diabetes mellitus (DM) using streptozotocin administration...

Helicobacter pylori and duodenogastric reflux are both recognised as playing aetiological roles in chronic gastritis. This study investigated whether H pylori colonisation of the antral mucosa and duodenogastric reflux are independent phenomena or have a causal relationship. Thirty eight patients (15 men, 23 women) aged (mean (SD)) 48 (17) years participated. Each patient underwent gastroscopy....

Inkubasi merupakan salah satu upaya dalam mengembangkan start-up. Beberapa institusi, seperti kampus dan pemerintah daerah, berupaya melakukan inkubasi untuk mempercepat lahirnya bisnis-bisnis baru. Pemerintah Provinsi Nusa Tenggara Barat membentuk lembaga baru menangani bernama BRIDA (Badan Riset Inovasi Daerah). Pertanyaannya adalah apakah proses ini sejalan dengan konsep yang sudah ada sebel...