CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase (ACAT) in vitro. Several in vivo approaches were used to determine the efficacy and sites of action of this compound in rats. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established ...

The belly spot and tail (Bst+/−) mouse phenotype is caused by mutations of the ribosomal protein L24 (Rpl24). Among various phenotypes in Bst+/− mice, the most interesting are its retinal abnormalities, consisting of delayed closure of choroid fissures, decreased ganglion cells and subretinal vascularization. We further characterized the Bst+/− mouse and investigated the underlying molecular me...

Influenzal encephalitis is frequently treated with oral antivirals, including amantadine (Symmetrel) for influenza A (if susceptible), rimantadine (Flumadine) for influenza A (if susceptible), and oseltamivir (Tamiflu) for influenza A and B; corticosteroids and immune globulin have also been tried. However, none of these agents has been proven to be effective for influenzal encephalitis. A comb...

The common marmoset (Callithrix jacchus), a New World primate species, is potentially a useful animal model for preclinical studies in drug development. However, cytochrome P450 (P450) enzymes have not been fully identified and characterized in marmosets. In this study, we identified P450 2A6 cDNA with the sequence highly identical (91–94%) to human P450 2A6, 2A7, and 2A13 cDNA and cynomolgus m...

In this paper the current situation of the management theory of organisations is examined and whether or not the NPOs need their own framework within this theory or not. Some authors have suggested that NPOs present special characteristics different from firms. From this perspective NPOs are a different group of organisations and the management theory of organisations have to develop in this ar...

Previous studies have shown that inhibition of a Golgi-complex-associated lysophospholipid acyltransferase (LPAT) activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum (ER). Here, we show that CI-976 stimulates tubule formation from all subcompartments of the Golgi complex, and often these tubules form...

Sample Size n = 30 n = 100 n = 250 Data Set / Method ACI Yang Jiang ACI Yang Jiang ACI Yang Jiang ThreePt .976 .893* .914* .961 .552* .945 .961 .387* .930* Magic .955 .999* .983* .977* .991* .969* .972* .997* .974* Mam. .957 .989* .966 .962 .996* .964 .960 .995* .968 Ion. .947 .995* .985* .948 .996* .970* .970 .990* .970* Donut .968 .966 .908* .969 .851* .971* .973* .898* .966 Bal. .979* .996* ...

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A cellular role and the mechanism of action for small GTPase Arl1 have been defined. Arl1-GTP interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on conserved residues of the GRIP domains that are important for Golgi targeting. The switch II region of Arl1 confers the specificity of this interaction. Arl1-GTP mediates Golgi recruitment of Golgin-97 in a switch II-de...