The complete resection for NSCLC is analyzed through the study of a series of retrospective surgical reports upon the incomplete resection, due to a microscopic residual tumor at the resection margin. Following Shields’ statement in 1974, the incomplete resection represents, in fact, the basic study protocol for the local recurrence following the resection of primary NSCLC. First of all, the ob...

Characterization of the circulating metabolites for a new chemical entity in humans is essential for safety assessment, an understanding of their contributions to pharmacologic activities, and their potential involvement in drug-drug interactions. This review examines the abundance of metabolites relative to the total parent drug [metabolite-to-parent (M/P) ratio] from 125 drugs in relation to ...

January 1, 2000 POCs Technical: Steve Vestal (612-951-7049, [email protected]) Jonathan Krueger (612-951-7642, [email protected]) Management: Tom Edman (612-951-7514, [email protected]) Business Development: Len Hones (612-951-7483, [email protected]) Export Control Officer: Cathy Angeles (612-951-7186, [email protected]) Intellectual Property: Pat ...

Zheng Q, et al. A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis. Aging (Milano) 2001; 13:112–21. 5. Kalso E. Opioids for persistent non-cancer pain: a team approach and individualisation of treatment are needed. BMJ 2005;330: 156–7. 6. Bannwarth B. Risk-benefit assessment of opio...

Lounela, Anu, Berglund, Eeva and Kallinen Timo (eds) 2019. Dwelling in Political Landscapes. Contemporary Anthropological Perspectives. Helsinki: SKS. Studia Fennica Anthropologica 4. 293 p. ISBN 978-951-858-087-7 (Print), 978-951-858-114-0 (PDF) 978-951-858-113-3 (EPUB). https://doi.org/10.21435/sfa.4.

We identified 255 loci across the human genome that contain genomic imbalances among unrelated individuals. Twenty-four variants are present in 410% of the individuals that we examined. Half of these regions overlap with genes, and many coincide with segmental duplications or gaps in the human genome assembly. This previously unappreciated heterogeneity may underlie certain human phenotypic var...

1 Assistant Professor (corresponding author) Department of Environmental Sciences 420 Geology Building University of California Riverside, CA 92521 V: (951) 827-2628 F: (951) 827-3993 [email protected] 2 Formerly: Postdoctoral Researcher Department of Environmental Sciences University of California Riverside, CA 92521 [email protected] 3 Associate Professor Department of Environmental...

Miwako Sakai1,2, Masafumi Kashiwahara3, Akiyoshi Kakita4 and Hiroyuki Nawa1* 1Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan 2Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 951-8510, Niigata, Japan 3Shin Nippon Biomedical Laboratories, Ltd., Miyanoura, Kagoshima 981-1394, Japan 4Department...