Background: In humans, CYP3A drug-metabolizing enzyme subfamily is the most important. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Often considered a precursor state for type II diabetes, metabolic syndrome exerts a modulating role on CYP3A, in our hypothesis. Objective: To evaluate the effect of metabolic syndrome on CYP3A drug-metabo...

Skeletal patterning in the sea urchin embryo requires a conversation between the skeletogenic primary mesenchyme cells (PMCs) and the overlyingpattern-dictatingectoderm;however, our understandingof the molecular basis for this process remains incomplete. Here, we show that TGF-β-receptor signaling is required during gastrulation to pattern the anterior skeleton. To block TGF-β signaling, we use...

Background: In humans, CYP3A drug-metabolizing enzyme subfamily is the most important. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Often considered a precursor state for type II diabetes, metabolic syndrome exerts a modulating role on CYP3A, in our hypothesis. Objective: To evaluate the effect of metabolic syndrome on CYP3A drug-metabo...

Background: In humans, CYP3A drug-metabolizing enzyme subfamily is the most important. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Often considered a precursor state for type II diabetes, metabolic syndrome exerts a modulating role on CYP3A, in our hypothesis. Objective: To evaluate the effect of metabolic syndrome on CYP3A drug-metabo...

Background: In humans, CYP3A drug-metabolizing enzyme subfamily is the most important. Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect CYP3A activity. Often considered a precursor state for type II diabetes, metabolic syndrome exerts a modulating role on CYP3A, in our hypothesis. Objective: To evaluate the effect of metabolic syndrome on CYP3A drug-metabo...

0747-5632/$ see front matter 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.chb.2013.01.004 q Part of this research has been presented at the 10th International Conference on Intelligent Virtual Agents, Reykjavik, Iceland, September 15–17, 2011 (Friedman, Hasler, Brovman, & Tuchman, 2011). ⇑ Corresponding author. Tel.: +972 54 524 2926; fax: +972 9 952 7650. E-mail addresse...

Karol Horodecki, Micha l Horodecki, Pawe l Horodecki, Jonathan Oppenheim Department of Mathematics Physics and Computer Science, University of Gdańsk, 80–952 Gdańsk, Poland Institute of Theoretical Physics and Astrophysics University of Gdańsk, 80–952 Gdańsk, Poland Faculty of Applied Physics and Mathematics, Technical University of Gdańsk, 80–952 Gdańsk, Poland and Department of Applied Mathem...

II Helsinki University Press Helsinki ISBN 952-10-0555-6 (Print) ISBN 952-10-0556-4 (Electronic Version)

Ravishankar Ramanathan,1, 2 Fernando G.S.L. Brandão,3, 4 Karol Horodecki,1, 5 Michał Horodecki,1, 2 Paweł Horodecki,1, 6 and Hanna Wojewódka1, 2, 7 National Quantum Information Center of Gdańsk, 81-824 Sopot, Poland Institute of Theoretical Physics and Astrophysics, University of Gdańsk, 80-952 Gdańsk, Poland Quantum Architectures and Computations Group, Microsoft Research, Redmond, WA (USA) De...

Karol Horodecki, Micha l Horodecki, Pawe l Horodecki, Debbie Leung, Jonathan Oppenheim Department of Mathematics, Physics and Computer Science, University of Gdańsk, 80–952 Gdańsk, Poland Faculty of Applied Physics and Mathematics, Technical University of Gdańsk, 80–952 Gdańsk, Poland Institute for Quantum Computing, University of Waterloo, Waterloo, Ontario, N2L1N8, Canada and Department of Ap...