In murine erythroleukemia (MEL) A20 cells (grown in 20 ng/ml adriamycin), mutation(s) producing 10-fold adriamycin (doxorubicin) resistance emerged via an unknown mechanism. Exposure of A20 cells to further stepwise increasing concentrations of ADR in combination with MDR modulators (PSC833 and verapamil) aimed to amplify the undetermined A20 mechanism while controlling P-glycoprotein (P-gp) ov...

In order to evaluate host immune response to cancer, many methods have been applied. However, in the field of oral squamous cell carcinoma, evaluation of host immune response on the basis of proliferative activity of tumor-infiltrating T-cells (TIL) has not been reported. Therefore, we applied double immunohistochemical staining of proliferation markers Ki-67 and CD8 to surgically resected and ...

Although leukoplakia is the most common precancerous lesion of the oral cavity, its molecular biological properties are largely unknown. The aim of this study was to identify the genes responsible for its pathogenesis and malignant transformation using oligonucleotide microarray technology. The expression profiles of 8,800 genes in human oral leukoplakia (n=4) and oral squamous cell carcinoma (...

In the article “Identifying Gaps in Asthma Education, Health Promotion, and Social Support for Mi’kmaq Families in Unama’ki (Cape Breton), Nova Scotia, Canada,” an error occurs in the first sentence of the Introduction. That sentence should read, “The health of Canada’s 1.5 million Aboriginal peoples (First Nations, Inuit, and Métis) (http://www.statcan.gc.ca/pub/89-645-x/2010001/count-pop-deno...

In the article “Factors Associated With Poor Glycemic Control or Wide Glycemic Variability Among Diabetes Patients in Hawaii, 2006-2009,” one of the funding sources for the study was not mentioned in the Acknowledgments section. The additional funding source is ARRA grant no. 3P20MD000173–09S1 from the National Institute on Minority Health and Health Disparities. The correction was made to our ...