Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

1 Professor of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences. Isfahan, Iran. 2 Assistant Professor of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences. Isfahan, Iran. 3 Resident of Ophthalmology, Isfahan Eye Research Center And Student Research Committee, School of Medicine, Isfahan University of Medical Sciences. Isfahan, I...

The transcriptional profiles of cardiac cells derived from murine embryos and from mouse embryonic stem cells (mESCs) have primarily been studied within a cell population. However, the characterization of gene expression in these cells at a single-cell level might demonstrate unique variations that cannot be appreciated within a cell pool. In this study, we aimed to establish a single-cell quan...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...

Masoumeh Sadeghi, Hamidreza Roohafza, Hamid Afshar, Fereshteh Rajabi, Mohamadarash Ramzani, Hasan Shemirani, Nizal Sarafzadeghan I Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences. Isfahan, IRAN. II Mental Health Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences. Isfahan, IRAN. III Psychiatry Department, Isfahan University o...

1 Associate Professor, Psychosomatic Research Center, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Associate Professor, Behavioral Sciences Research Center, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 3 Resident, Behavioral Sciences Research Center, Department of Psychiatry, School...

1Student, Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran 2Assistant Professor, Biosensor Research Center and Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 3Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 4Assistant Professor, Department of Basic Scien...

Vahid Shaygannejad, Khodayar Golabchi, Alireza Dehghani, Fereshteh Ashtari, Sepehr Haghighi, Mahsa Mirzendehdel2, Majid Ghasemi1 Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Student of Medicine, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Ophtalmology, Isfahan ...