It has been proposed that in humans 4b-hydroxycholesterol is formed mainly by CYP3A-catalyzed metabolism of cholesterol and thus may serve as an endogenous marker for CYP3A activity. The cynomolgus monkey is widely used as one of the nonrodent preclinical safety species in pharmaceutical research. In the current study, the potential application of 4b-hydroxycholesterol as an endogenous biomarke...

It has been proposed that in humans 4b-hydroxycholesterol is formed mainly by CYP3A-catalyzed metabolism of cholesterol and thus may serve as an endogenous marker for CYP3A activity. The cynomolgus monkey is widely used as one of the nonrodent preclinical safety species in pharmaceutical research. In the current study, the potential application of 4b-hydroxycholesterol as an endogenous biomarke...

INTRODUCTION Discovery of hormones and endocrine phenomena: Experimental work in endocrinology is an excellent example for the reductionist view of biology. This view point, which is currently in fashion, asserts that the laws of physics and chemistry are sufficient to understand and to ‘explain’ biological phenomena. While this statement will not be discussed any further, it cannot be helped s...

http://bmj.com/cgi/content/full/330/7495/839 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/330/7495/839/DC1 "Summary of reviews and extra references" References http://bmj.com/cgi/content/full/330/7495/839#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/330/7495/839#BIBL...

MR imaging was used to evaluate the relationship of the root exit zone of the seventh cranial nerve to surrounding vascular structures in 13 patients with clinically documented hemifacial spasm and in 70 asymptomatic patients. MR imaging clearly demonstrated the course of the seventh nerve from the root exit zone of the brainstem to the internal auditory canal and its relationship to the surrou...

Cancer cells employ glutaminolysis to provide a source of intermediates for their upregulated biosynthetic needs. Glutaminase, which catalyzes the conversion of glutamine to glutamate, is gaining increasing attention as a potential drug target. Small-molecule inhibitors such as BPTES and CB-839, which target the allosteric site of glutaminase with high specificity, demonstrate immense promise a...