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gateway to understanding intelligence in brains and machines, to discovering how the human brain works and to making intelligent machines that learn from experience. What distinguishes nontrivial learning from memory is the ability to generalize: that is, to apply what has been learned from limited experience to new situations. Memory bears the same relationship to learning as a dry list of exp...

Wickham Chen, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected] Tiankuan Liu, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1541. Fax: 214-768-4095. Email: [email protected] Junheng Zhang, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected]...

Wickham Chen, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected] Tiankuan Liu, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1541. Fax: 214-768-4095. Email: [email protected] Ping Gui, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1733. Fax: 214-768-3573. Email: [email protected] Annie C...

Wickham Chen, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected] Cheng-An Yang, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1641. Fax: 214-768-4095. Email: [email protected] Junheng Zhang, Southern Methodist University, Dallas, TX, 75275. Phone: 214-768-1402. Fax: 214-768-3573. Email: [email protected]...

Radiotherapy, a therapeutic modality of cancer treatment, nonselectively damages normal tissues as well as tumor tissues. The search is ongoing for therapeutic agents that selectively reduce radiation-induced normal tissue injury without reducing tumoricidal effect, thereby increasing the therapeutic ratioof radiation therapy. Our laboratory established 5-(4-methylpiperazin-1-yl)2-[2ʹ-(3,4-dime...

Blow flies of the genus Hypopygiopsis are considered forensically important. In Thailand, four Hypopygiopsis species coexist, i.e., Hypopygiopsis fumipennis, Hypopygiopsis infumata, Hypopygiopsis violacea and Hypopygiopsis tumrasvini. In this study, the ontogeny and developmental rate of H. tumrasvini eggs, larvae and pupae were determined in the laboratory chamber reared at 25.0±2.0°C and 80.0...

In this issue of Rheumatology, Gaujoux-Viala et al. [1] studied a cohort (ESPOIR) with early rheumatoid arthritis (ERA) where 813 patients were followed up for more than 2 years and rated their quality of life (QoL). This valuable study demonstrates that initially 11% and later 3.3% have a utility that is worse than death, which translates as death being a better quality of life than their curr...

p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in...