In this article we describe a new methodology for the total synthesis of 3,4-unsubstituted coumarins from commercially available starting materials. Six examples were prepared, including five naturally occurring coumarins--7-hydroxy-6,8-dimethoxy-coumarin (isofraxidin), 7-hydroxy-6-methoxycoumarin (scopoletin), 6,7,8-trimethoxy-coumarin, 6,7-dimethoxycoumarin (scoparone), and 7,8-dihydroxycouma...

Present work describes the synthesis of coumarin Mannich bases 4-7 by the application of Mannich reaction on 7-hydroxy-4-methyl coumarin 3 using conventional as well as microwave technology to compare the feasibility, reaction time and yield of the product. For this, 7-hydroxy-4-methyl coumarin 3 was prepared using Pechmann condensation reaction and Mannich bases (4-7) were synthesized by the r...

Investigation of the aerial parts of the Egyptian medicinal plant Ammi majus L. led to isolation of new coumarin, 6-hydroxy-7-methoxy-4 methyl coumarin (2) and 6-hydroxy-7-methoxy coumarin (3); this is the first time they have been isolated from this plant. The structures of the compounds (2 &3) were elucidated by spectroscopic data interpretation and showed anti-inflammatory and anti-viral act...

Development and Validation of a New Simple Liquid Chromatographic Method for Determination Coumarin its 7-Hydroxy Metabolite as Marker Cytochrome P450 2A6 in RatsSundeep Bath, Wael Ebied, Hytham Ahmed, Fawzy Elbarbry

7-hydroxy coumarin undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine, and bysubstituation the corresponding aryl vinyl ethers was obtained in good yields

The mechanism of base to base intermolecular proton shuttling occurring in the excited state proton transfer reaction between 7-hydroxy-4-(trifluoromethyl)coumarin (CouOH) and concentrated 1-methylimidazole base (1-MeId) in toluene solution is disclosed here by means of a computational approach based on Density Functional Theory (DFT) and Time Dependent DFT (TD-DFT). These methods allow us to c...

Skimmia laureola Hook (Rutaceae) is found in Kashmir and in the mountains of Northern Pakistan and is used in folklore medicine for the treatment of various ailments [1 – 3]. The quinoline alkaloids of this plant have demonstrated antifungal and immunomodulating properties [4, 5]. The ethanolic extracts of the aerial parts of S. laureola are active against the animal pathogen Microsporium canis...

Coumarin possesses a number of biological activities like antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antimalarial etc. Coumarin belongs to a group of benzpyranes, which consist of a benzene ring joined to a pyran nucleus. In the present study amino derivatives bearing coumarin nucleus are synthesized from 7-hydroxy -4methyl coumarin by using mild catalyst, CAN which i...