نتایج جستجو برای: 69.6
تعداد نتایج: 1508 فیلتر نتایج به سال:
Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due tomutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2. RyR2 were isolated from sheep heart, incorpor...
Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly in skeletal muscle and reduced during C2C12 myoblasts differentiation. MiR-69...
This work presents a critical assessment of the state and quality of knowledge around the aquatic photochemistry of humanand veterinary-use pharmaceuticals from laboratory experiments and field observations. A standardized scoring rubric was used to assess relevant studies within four categories: experimental design, laboratory-based direct and indirect photolysis, and field/solar photolysis. S...
Background: Obesity is the most important risk factor for obstructive sleep apnea (OSA). Weight-reduction programs have been observed to represent effective treatment of overweight patients with OSA. However, it is not known whether beneficial changes remain after the end of the intervention. Objective: The aim of the study was to assess the long-term efficacy of a lifestyle intervention based ...
Based on the Barings Bank case study from Chapter 1 This case study is found in Chapter 1 of the textbook, but the analysis I present here incorporates ideas from several chapters of the book. Included in the analysis here are the following concepts: Chapter 3: Contracting costs and the existence of firms Chapter 5: Economies of scale and scope Chapter 6: Perfect competition Chapter 10: Asymmet...
The contractile state of smooth muscle (SM) reflects the ratio of activities of myosin light-chain kinase (MLCK) and myosin light chain phosphatase (MLCP), which determines the extent of regulatory light chain (RLC) phosphorylation and actin-activated myosin II activity and can be changed by modulating the activities of the calcium-calmodulin–dependent MLCK or of MLCP. Agonists through G protei...
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