Parkinson's begins when a certain class of brain cells begins to die, cells that produce a chemical called dopamine, which your body needs. Dopamine serves as a chemical messenger helping to control muscle activities. Loss of dopamine leads to the progressive loss of muscular control, giving rise to a variety of symptoms: stiffness, tremor, slow movement, difficulty with balance, difficulty wal...

Nemaline myopathy (NM) is one of the most common forms of congenital myopathy, and affects either fast myofibers, slow myofibers, or both. However, an animal model for congenital myopathy with fast-myofiber-specific atrophy is not available. Furthermore, mutations in the leiomodin-3 (LMOD3) gene have recently been identified in a group of individuals with NM. However, it is not clear how loss o...

The Federalist Papers were written in 1787-1788 by Alexander Hamilton, John Jay and James Madison to persuade the citizens of the State of New York to ratify the U.S. Constitution. As was common in those days, these 77 shorts essays, about 900 to 3500 words in length, appeared in newspapers signed with a pseudonym, in this instance, “Publius”. In 1778 these papers were collected along with eigh...

The nonimmunosuppressive cyclophilin (Cyp) inhibitor SCY-635 blocks hepatitis C virus (HCV) replication both in vitro and in vivo and represents a novel potent anti-HCV agent. However, its mechanism of action remains to be fully elucidated. A growing body of evidence suggests that cyclophilin A (CypA) is absolutely necessary for HCV replication and that the HCV nonstructural 5A (NS5A) protein s...

SCY-635 is a novel nonimmunosuppressive cyclosporine-based analog that exhibits potent suppression of hepatitis C virus (HCV) replication in vitro. SCY-635 inhibited the peptidyl prolyl isomerase activity of cyclophilin A at nanomolar concentrations but showed no detectable inhibition of calcineurin phosphatase activity at concentrations up to 2 microM. Metabolic studies indicated that SCY-635 ...

Inhibition of cyclooxygenase (COX) and prostaglandin E(2) (PGE(2)) protects cells against cell injury in specific pathophysiological situations: inflammation and oxidative stress. Although the anti-inflammatory effects have been reported in clinical fields for specific wavelength irradiation during wound healing, the physiological mechanism has not been clarified yet. The aim of the present stu...

1Department of Occupational Therapy, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA 2Program in Rehabilitation Sciences, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA 3Department of Medicine, Boston University Medical Center, 1 Boston Medical Center Place, Boston, MA 02118, USA 4Undergraduate Program in Neuroscience, Boston University, 2 Cummington Mall, B...

Partitioning of organic solutes between water and polyamide layer of RO and NF membranes: Correlation to rejection Adi Ben-David a, Sarit Bason a, Juergen Jopp b, Yoram Oren a, Viatcheslav Freger a,c,∗ a Department of Desalination and Water Treatment, Zuckerberg Institute for Water Research and Unit of Environmental Engineering, Ben-Gurion University of the Negev, POB 635, Beer-Sheva 84105, Isr...