The pharmacological properties of the 5-hydroxytryptamine (HT)(1A) receptor agonist (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide (NAE-086) were examined with in vitro and in vivo techniques. Receptor binding studies demonstrated that NAE-086 was a high-affinity and selective 5-HT(1A) receptor ligand with a K(i) value of 4.5 nM in membranes from rat hip...

The reactivity of lignin model compounds under Mannich conditions with piperidine and formaldehyde was studied. The piperidinomethyl group was confirmed to be introduced quantitatively at sterically unhindered positions ortho to a phenolic hydroxyl when the substrate was allowed to react under ambient conditions. The sequential application of the Mannich reaction followed by quantitative P NMR ...

Background: Sugar-sweetened soft drinks have been linked to a number of adverse health outcomes such as high weight gain. Therefore, artificially sweetened soft drinks are often promoted as an alternative. However, the safety of artificial sweeteners has been disputed, and consequences of high intakes of artificial sweeteners for pregnant women have been minimally addressed. Objective: We exami...

J Med Assoc Thai Vol. 93 Suppl. 2 2010 Correspondence to: Hamontri S, HRH Princess Maha Chakri Sirindhorn Medical Center, Department of Obstetrics and Gynaecology, Faculty of Medicine, Srinakharinwirot University, Rangsit-Nakohn Nayok Rd, Nakohn Nayok 26120, Thailand. Phone: 037-395-086 Ext. 10803, Fax: 037-395-086 Ext. 10801. E-mail: [email protected] Predictive Factors for Residual Disease...

Trichuris dysentery syndrome is caused by Trichuris trichiura which contributes to one of the most common helminthic infections in the world. It is associated with heavy colonic infection that manifests as mucoid diarrhoea, rectal bleeding, rectal prolapse, iron deficiency anaemia, and finger clubbing. Here, we report a case of trichuris dysentery syndrome complicated with severe chronic iron d...

Methods for seeding high-viability (>85%) three-dimensional (3D) alginate-chondrocyte hydrogel scaffolds are presented that employ photocrosslinking of methacrylate-modified alginate with the photoinitiator VA-086. Comparison with results from several other photoinitiators, including Irgacure 2959, highlights the role of solvent, ultraviolet exposure, and photoinitiator cytotoxicity on process ...

1 2 3 4 5 6 Molecular Darwinian evolution of virulence in Yersinia pestis 7 8 9 10 Dongsheng Zhou, and Ruifu Yang 11 12 State Key Laboratory of Pathogen and Biosecurity, 13 Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China 14 15 16 17 Correspondence: 18 Dongsheng Zhou, Associate Professor, Ph.D. 19 E-mail: [email protected] 20 Tel: 086-10-66948594 21 22 Ruifu Y...

Polystyrene-silica core-shell composite particles are prepared by one-step emulsion polymerization with a nonionic initiator VA-086, solely stabilized by silica nanoparticles. The silica nanoparticles are successfully incorporated as the shell, likely due to the fact that the nanoparticles are thermodynamically favorable to adsorb and remain at the liquid-liquid interfaces during the emulsion p...