نتایج جستجو برای: 6.91
تعداد نتایج: 1670 فیلتر نتایج به سال:
Achieving information content of satisfactory breadth and depth remains a formidable challenge for proteomics. This problem is particularly relevant to the study of primary human specimens, such as tumor biopsies, which are heterogeneous and of finite quantity. Here we present a functional proteomics strategy that unites the activity-based protein profiling and multidimensional protein identifi...
European studies have revealed that the ABCB11 c.1331T>C (V444A) polymorphism (rs2287622) C-allele frequency is higher among patients with drug-induced cholestasis. Given the low incidence of this disease, however, this association has not been sufficiently elucidated. We aimed to investigate the significance of this polymorphism in Japanese patients. We determined ABCB11 V444A polymorphism fre...
Over-nutrition in females causesaltered fetal growthduringpregnancy and permanently programs the metabolism of offspring; however, the temporal and mechanistic origins of these changes, and whether they are reversible, are unknown. We now show that, in obese female mice, cumulus-oocyte complexes exhibit endoplasmic reticulum (ER) stress, high levels of intracellular lipid, spindle abnormalities...
Acute schistosomiasis is characterized by pro-inflammatory responses against tissueor organ-trapped parasite eggs along with granuloma formation. Here, we describe studies in Cx3cr1 mice and demonstrate the role of Cx3cr1 in the pathoetiology of granuloma formation during acute schistosomiasis. Mice deficient in Cx3cr1 were protected from granuloma formation and hepatic injury induced by Schist...
clinical care without having to demonstrate that they are achieving acceptable standards. Several factors are contributing to a dilution of this implicit trust and to increasing demands for explicit evidence about the performance of the medical profession. Some of these factors represent social trends; for example, the de-professionalization of society, demands for greater accountability of pub...
Three strains of Legionella feeleii from patients with pneumonia (425-MI-H, 691-WI-H, and 693-WI-H) and one environmental strain (713-MI-E) received at the Centers for Disease Control for reference diagnostic testing were compared with the type strain WO-44C-C3 (ATCC 35072) by DNA hybridization, chemical analysis of cellular fatty acids and ubiquinones, biochemical tests, and serological charac...
Here, ERPs were employed to characterise the residual face processing of FE, a patient with extensive damage to the ventral temporal-occipital cortex and a dense prosopagnosia. A large N170 was present in FE and he performed well in tests of face structural processing. Covert recognition of the faces of personal acquaintances was demonstrated with P300 oddball experiments. The onset latency of ...
The PARC 700 dependency bank has a number of features that would seem to make it less than optimally suited for its intended purpose, parser evaluation. However, it is difficult to know precisely what impact these problems have on the evaluation results, and as a first step towards making comparison possible, a subset of the same sentences is presented here, marked up using a different format t...
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