BACKGROUND Serotonin (5HT) has been shown to be a mitogenic factor in several carcinomas. Its mitogenic effect is elicited through a wide range of 5HT receptor subtypes. In this study, the effects of 5HT, 5HT3 (1-phenylbiguanide hydrochloride) and 5HT4 (cisapride) agonists in promoting the growth of the HT29 cell line and the growth-inhibition effect of the 5HT3 receptor antagonist (Y-25130 hyd...

abstract fixed drug eruption (fde) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. fde is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. a 27-year-old woman presented with multiple dark patches over her eyelid...

cancer patient receive various cytotoxic drugs in association with antiemetic drugs such as 5ht3 receptor antagonists as their chemotherapy regimen. 5ht3 receptor antagonists have been reported to produce changes in ecg parameter. there are only a few studies about cardiovascular events of these drugs in patient receiving potentially cardiotoxic chemotherapies. the subject of this study is to e...

antiemetics 5-Hydroxytryptamine type 3 receptor (5HT3) (serotonin) antagonists, corticosteroids and aprepitant are usually given once daily. However, for delayed emesis corticosteroids are given two times daily. Dopamine antagonists are given three or four times daily. For routine use oral doses are recommended [I, A]. Palonosetron is only available as an i.v. formulation. Substances of the sam...

Acetone extract of Z. oficinale (AEZ) possessing anti-5HT effect which can be related to antagonism of 5HT3 receptors. 5HT3 receptor antagonists improve basal performance in rhodent and primate tests of cognition and inhibit the cognitive impairments.Material & methods: Spontaneous alteration task paradigm using Y-maze, transfer latency on elevated plus maze, estimation of brain acetylcholinoes...

Background. 5HT3 antagonist, an antiemetic alternative to dexamethasone, is an effective drug for the prevention of postoperative nausea and vomiting (PONV). Methods. PubMed and The Cochrane Library (from inception to June 2016) were searched for relevant RCTs (randomized controlled trials). Results. Seven trials, totaling 682 patients, were included in this meta-analysis. This meta-analysis de...

YM060, (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, is a new serotonin (5HT)3-receptor antagonist. We examined the effects of YM060 on chemotherapeutic agent-, apomorphine- and copper sulfate-induced emesis. Intravenous YM060 potently prevented cisplatin (10 mg/kg, i.v.)-induced emesis with ED50 values of 0.06 (0.05-0.07) micrograms/kg, i.v. in ferrets...

The aim of this article is to review the pathophysiology and clinical role of serotonin receptor modulators used in the treatment of irritable bowel syndrome. Serotonin is an important monoamine neurotransmitter that plays a key role in the initiation of peristaltic and secretory refl exes, and in modulation of visceral sensations. Several serotonin receptor subtypes have been characterized, of...