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R. EASTELL, D.M. REID, J. COMPSTON, C. COOPER, I. FOGELMAN, R.M. FRANCIS, S.M. HAY, D.J. HOSKING, D.W. PURDIE, S.H. RALSTON, J. REEVE, R.G.G. RUSSELL1 and J.C. STEVENSON From the University of Sheffield Medical School, Sheffield, University of Aberdeen, Aberdeen, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, University of Southampton, Southampton, Guy’s...
ABCG2 (ATP-binding cassette, subfamily G, member 2) is a plasma membrane glycoprotein that actively extrudes xenobiotics and endobiotics from the cells and causes multidrug resistance in cancer. In the liver, ABCG2 is expressed in the canalicular membrane of hepatocytes and excretes its substrates into the bile. ABCG2 is known to require high membrane cholesterol content for maximal activity, a...
of the 7th European Nonlinear Dynamics Conference (ENOC), Rome, Italy, July 2011. Kiehn O. 2006. Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci 29:279–306. Kiorboe T, Jiang H, Colin SP. 2010. Danger of zooplankton feeding: the fluid signal generated by ambush-feeding copepods. P Roy Soc B Biol Sci 277:3229–37. Koehler C, Wischgoll T, Dong H, Gaston Z. 2011. Vortex visualizat...
Nutritional interventions that might influence sarcopenia, as indicated by literature reporting on sarcopenia per se as well as dynapenia and frailty, are reviewed in relation to potential physiological aetiological factors, i.e. inactivity, anabolic resistance, inflammation, acidosis and vitamin D deficiency. As sarcopenia occurs in physically active and presumably well-nourished populations, ...
The sex of primordial germ cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells. In XY gonads, sexdetermining region Y (SRY) triggers fibroblast growth factor 9 (FGF9) expression in somatic cells. FGF signaling, together with downstream nodal/activin signaling, promotesmale differentiation in XY germ cells by suppressing retinoic acid (RA)-dependent meiotic en...
Michael N Weedon1,2,23, Hana Lango1,2,23, Cecilia M Lindgren3,4, Chris Wallace5, David M Evans6, Massimo Mangino7, Rachel M Freathy1,2, John R B Perry1,2, Suzanne Stevens7, Alistair S Hall8, Nilesh J Samani7, Beverly Shields2, Inga Prokopenko3,4, Martin Farrall9, Anna Dominiczak10, Diabetes Genetics Initiative21, The Wellcome Trust Case Control Consortium21, Toby Johnson11–13, Sven Bergmann11,1...
Biochemical Studies Blood Uridine Diphosphate Glucose in Mental Disease; by OttoHansen . . . . 557 The Investigation ofHomovanillic Acid in the Human Brain and its Correlation to Senile Dementia; byC. G. Gotifries, I. Gottfries andB. E. Root . . . . . . 563 Adrenocortical Responsiveness during Courses of Electro-convulsive Therapy; by A. Elithorn, P.1. Bridges,J. R.HodgesandM. T.Jones . . . . ....
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