BACKGROUND AND PURPOSE NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the safety of NXY-059 in patients with intracerebral hemorrhage (ICH). METHODS We randomized 607 patients within 6 hours of acute ICH to receive 2270 mg intravenous NXY-059 over ...

1 AGH University of Science and Technology, Faculty of Mechanical Engineering and Robotics, al.Mickiewicza 30, 30-059 Cracow, Poland, [email protected] 2 AGH University of Science and Technology, Faculty of Electrotechnics, Automation, Computer Science and Biomedical Engineering, al. Mickiewicza 30, 30-059 Cracow, Poland [email protected] 3 Jagiellonian University, Faculty of Physics, Astr...

JANUSZ OCHONSKI Department of Robotics and Mechatronics AGH University of Science and Technology Al. Mickiewicza 30, 30-059 Kraków [email protected] LUKASZ AMBROZINSKI Department of Robotics and Mechatronics AGH University of Science and Technology Al. Mickiewicza 30, 30-059 Kraków [email protected] ANDRZEJ KLEPKA Department of Robotics and Mechatronics AGH University of Sc...

NXY-059 is a nitrone compound with free radical trapping properties that appears to be neuroprotective in some animal models of stroke.1,2 The publication this month of SAINT-I trial in the New England Journal of Medicine3 demonstrates a small but statistically significant improvement of the primary outcome by NXY-059 treatment. The authors observed reduced disability at 90 days as assessed by ...

In a ongoing programme aimed at studying galaxy counterparts of Damped Lyα Absorbers (DLAs) we have obtained high resolution deep I-band imaging data of the field around the z em = 0.457 BAL QSO Q2112+059. In the literature this QSO is listed to have a candidate DLA at z abs = 0.2039 along the line of sight. After subtraction of the QSO Point Spread Function (PSF) we detect a galaxy centred on ...

BACKGROUND AND PURPOSE Increased free radical formation contributes to the damage caused to the brain by acute ischemia. NXY-059 is a nitrone-based free radical trapping agent in development for acute stroke. NXY-059 has neuroprotective efficacy when given 5 hours after onset of transient focal ischemia in the rat. METHODS This was a randomized, double-blind, placebo-controlled, parallel grou...

INTRODUCTION Pancreatic cancer is an aggressive cancer and its prognosis remains poor. Therefore, additional effective therapy is required to augment and/or complement current therapy. CD147, high expression in pancreatic cancer, is involved in the metastatic process and is considered a good candidate for targeted therapy. CD147-specfic imaging could be useful for selection of appropriate patie...

BACKGROUND Next-generation sequencing (NGS) has transformed genomic research by reducing turnaround time and cost. However, no major breakthrough has been made in the upstream library preparation methods until the transposase-based Nextera method was invented. Nextera combines DNA fragmentation and barcoding in a single tube reaction and therefore enables a very fast workflow to sequencing-read...