Background. The number of people residing in nursing homes has increased. General practitioners (GPs) receive an increased capitation fee for elderly patients in recognition of their higher consultation rate. However, there is no distinction between elderly patients residing in nursing homes and those in the community. Aim. To determine whether nursing home residents receive greater general pra...

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67 knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice. These include pulmonary hypopla...

The packets in a mobile wireless ad-hoc network (MANET) are vulnerable to various packet-dropping attacks. Due to the lack of a centralized monitoring mechanism, it is a challenging problem to identify the attackers that launch the packet-dropping attacks in MANET. The existing DoS defensive techniques have not provided a scheme to efficiently and effectively solve this challenging problem. Hen...

Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical probe that modulates SIRT1-associated biological processes. However, the effect of EX-527 on neur...

A current model for the regulation of the Src protein-tyrosine kinase proposes that the COOH-terminal phosphotyrosine, Tyr-527, binds to the Src homology 2 (SH2) region in an intramolecular interaction that represses the kinase domain. This model is consistent with the activation of Src by mutations in the SH2 domain or COOH terminus. Mutations in the SH3 domain also activate Src, although this...

Phosphorylation of pp60c-src by p34cdc2 at three amino-proximal serine/threonine residues is temporally correlated with, but insufficient for, mitotic activation of c-Src kinase. The direct cause of activation during mitosis appears to be temporally correlated partial dephosphorylation of Tyr-527, a residue whose phosphorylation strongly suppresses pp60c-src activity. Site-directed mutagenesis ...

The collection of k-closed subsets of X forms a topology, which contains the original topology of X (i.e. closed subsets are always k-closed). Notation 1.2. Let kX denote the space whose underlying set is that of X, but equipped with the topology of k-closed subsets of X. Because the k-topology contains the original topology on X, the identity function id : kX → X is continuous. Definition 1.3....