BACKGROUND miRNAs are critical post-transcriptional regulators of gene expression and key mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor progression, but its biological role and mechanism remain largely unknown. This study is aimed to study the role of miR-501-5p in the progression of gastric cancer. METHODS Real-time PCR analysis was used to determine...

OBJECTIVE To demonstrate pharmacokinetic (PK) similarity of biosimilar candidate ABP 501 relative to adalimumab reference product from the USA and European Union (EU) and evaluate safety, tolerability and immunogenicity of ABP 501. METHODS Randomised, single-blind, single-dose, three-arm, parallel-group study; healthy subjects were randomised to receive ABP 501 (n=67), adalimumab (USA) (n=69)...

Using an implanted electrode, we recorded the responses from the ultrasound-sensitive mantis interneuron 501-T3 during flying bat attacks in a large flight room where the mantis served as the target. 501-T3 responds to each vocalization emitted with multi-spike bursts when pulse repetition rates (PRRs) are below 55 pulses x s(-1). As PRR increases and pulse durations fall below 3 ms, 501-T3 cea...

Purpose: This study aimed to first investigate synchronous (SYN) versus asynchronous (ASY) mode of propulsion and, second, investigate the wheel camber effects on sprinting performance as well as temporal parameters. Method: Seven wheelchair basketball players performed four maximal eight-second sprints on a wheelchair ergometer. They repeated the test according to two modes of propulsion (SYN ...

The Z-selective cross metathesis of allylic-substituted olefins is explored with recently developed ruthenium-based metathesis catalysts. The reaction proceeds with excellent stereoselectivity for the Zisomer (typically >95%) and yields of up to 88% for a variety of allylic substituents. This includes the first synthesis of Z-a,b-unsaturated acetals by cross metathesis and their elaboration to ...

Problem 1 [30 points]: Consider a ring network with nodes 1,2,...,K. In this network, a customer that completes service at node i exits the network with probability p, or it is routed to node i+1 with probability 1-p, for i = 1,2,...,K-1. Customers that complete service at node K, either exit the network, or are routed to node 1, with respective probabilities p and 1-p. At each node, external c...

Aperture Uncertainty One of the key concerns when performing IF sampling is that of aperture jitter or aperture uncertainty. The terms aperture jitter and aperture uncertainty are frequently interchanged in text. In this application, they have the same meaning. Aperture uncertainty is the sample-tosample variation in the encode process. Aperture uncertainty has three residual effects: the first...