551 Hallux abducto valgus is one of the most common deformities encountered in podiatric medical practice. Hallux abducto valgus, commonly referred to as a bunion, may have two components: a rigid or structural component and a dynamic or flexible one. One component usually predominates over the other. The dynamic or flexible component is reducible clinically or after lateral soft-tissue release...

Peroxisome-proliferator responsive element (PPRE) and nuclear factor-κB (NF-κB) response element have been found in the gene sequence of superoxide dismutase (SOD). This study determines the PPARs and NF-κB expression and SOD activity in damaged livers of rats with obstructive jaundice. Sprague-Dawley rats (n = 120) were randomly assigned into four groups: sham 7 days post-surgery (Sham 7), bil...

Genitourinary amoebiasis is a rare form of kidney and urinary tract infection caused by Entamoeba histolytica. Here, we describe the first case of unusual infection caused by E. histolytica in Bueng Kan province, northeast, Thailand. A 63-year-old female patient was diagnosed as acute pyelonephritis. E. histotolytica trophozoites were accidentally found in urine collected from a catheter.

Malaria remains a major public health problem causing mortality and morbidity in tropical and subtropical countries. A cross-sectional study was carried out to determine malaria prevalence and its clinical pattern during malaria season in Yemen. Blood samples were collected from 511 patients with fever who voluntary participated in this study, of them 268 were males and 242 females. Malaria was...

Economies at early stages of development are often shaken by abrupt changes in growth rates, whereas in advanced economies growth rates tend to be relatively stable. To explain this pattern, we propose a theory of technological diversification. Production makes use of different input varieties, which are subject to imperfectly correlated shocks. Technological progress takes the form of an incre...

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin signaling as well as insulin signaling. JTT-551 is a new PTP1B inhibitor, which is reported to improve glucose metabolism by enhancement of insulin signaling. We have evaluated an antiobesity effect of JTT-551 using diet-induced obesity (DIO) mice. A single administration of JTT-551 was provided to DIO mice with or withou...

L. Vättern is the second largest lake (approx. 130 x 30 km surface) in Sweden and one of the largest freshwater bodies (volume 74 km) in Europe (Fig. 1). The lake is of great national interest and is protected by law for recreation, national defense, natural and cultural interests, etc. L. Vättern is a unique ecosystem with glacial relicts as, e.g. the amphipods Monoporeia affinis, Gammaracanth...

BACKGROUND To date, no treatment for neuromyelitis optica (NMO) has been granted regulatory approval, and no controlled clinical studies have been reported. OBJECTIVE To design a placebo-controlled study in NMO that appropriately balances patient safety and clinical-scientific integrity. METHODS We assessed the "standard of care" for NMO to establish the ethical framework for a placebo-cont...

BACKGROUND Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the pathogenesis of SSc. MEDI-551 is an investigational humanized monoclonal antibody that targets the B cell surface antigen CD19 and mediates antibody-dependent, cell-mediated cy...