INTRODUCTION Therapy comprising 5-fluorouracil, levofolinate, and oxaliplatin is currently the most common chemotherapy for colorectal cancer. We experienced a successful case of advanced colon cancer and recurrent breast cancer with 5-fluorouracil, levofolinate, and oxaliplatin therapy. CASE PRESENTATION A 43-year-old Japanese woman who had already undergone surgery three times for bilateral...

Cancer deaths increase every year, including in Indonesia. The low selectivity of chemotherapy agents and the resistance cancer cells against is main cause treatment failure. It causes serious side effects sufferers. Beside that, plants produce secondary metabolites which are being investigated for anticancer activity that used as new clinical drugs. Therefore we need research uses co-chemother...

Introduction: Recently, nanographene oxide (NGO) is proven to be as a great candidate for drug delivery, and phototherapies cancer. Photothermal sensitivity of NGO and its optical absorption in the NIR region lead to photothermal ablation of tumors. Nevertheless, the major drawback of GO is its toxicity in biological systems, To overcome this problem, nanoscale GO prepare with...

objective: the purpose of this study was to observe the effects of methoxyamine (mx) on the cytotoxic effects and dna damage caused by 5-fluorouoracil (5-fu), in combination with gamma-rays in human colon cancer cell line. materials and methods: in this experimental study, ht29 cells were cultured as a monolayer and treated with different concentrations of 5-fu along with 1 mm mx for 24 h. afte...

Background: Solid tumors may occur in 3% of the patients with chronic myeloid leukemia (CML). In this paper, we presented a case of CML following treatment of colon cancer. Case Presentation: A 25 year old man was diagnosed of adenocarcinoma of rectosigmoid treated with fluorouracil-based chemotherapy. Following relapse, he received florouracil, oxaliplatin and irinotecan during the next year. ...

OBJECTIVE Mucositis is a serious disorder of the gastrointestinal tract that results from cancer chemotherapy. We investigated the effects of increasing grape seed extract doses on the severity of chemotherapy in a rat model and its coincident impact on chemotherapeutic effectiveness in colon cancer cells. DESIGN Female Dark Agouti rats were gavaged with grape seed extract (400-1000 mg/kg) or...

The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotype...