A method is provided for suppressing atherogenesis in which a cholesterol 20-hydroperoxide is administered, which is preferably one or both of the novel compounds: 20(R)-hydroperoxy-25-hydrocholesterol and 29(S)hydroperoxy-25-hydrocholesterol 20(R)-hydroperoxy-25 hydrocholesterol and 20(S)-hydroperoxy-25-hydrocholesterol are administered. The compositions 20(R)-hydroperoxy-25-hydrocholesterol a...

Pyrazoles and isoxazoles are well-known important heterocyclic compounds that due to their participation in the structure of many drugs are very important. Pyrazoles and isoxzaloes can be prepared by oxidation of pyrazolines and isoxazolines respectively. In this work, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxalane (DHPDMDO)/NH4I has been used as a new, powerful, nearly green, effective and...

Pyrazoles and isoxazoles are well-known important heterocyclic compounds that due to their participation in the structure of many drugs are very important. Pyrazoles and isoxzaloes can be prepared by oxidation of pyrazolines and isoxazolines respectively. In this work, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxalane (DHPDMDO)/NH4I has been used as a new, powerful, nearly green, effective and...

Arachidonate 5-lipoxygenase was purified to near homogeneity from the 105,000 X g supernatant of porcine leukocyte homogenate by immunoaffinity chromatography using a monoclonal anti-5-lipoxygenase antibody. Reaction of the purified enzyme with arachidonic acid produced predominantly 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid with concomitant formation of several more polar compounds in smal...