نتایج جستجو برای: 5-Nitrofuran

تعداد نتایج: 1215932  

Journal: :Chemical communications 2014
Enrique E Maroto Marta Izquierdo Michihisa Murata Salvatore Filippone Koichi Komatsu Yasujiro Murata Nazario Martín

A complete stereocontrol of 1,3-dipolar cycloaddition of N-metalated azomethine ylides onto endohedral fullerene H2@C60 is reported for the first time. The stereodivergent synthesis of either the cis or the trans endohedral cycloadduct is achieved with excellent diastereo- and enantioselectivities.

Journal: :Organic letters 2005
Wenzhong Gao Xumu Zhang Malati Raghunath

[reaction: see text] A novel Cu(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with acrylates has been developed. Up to 98/2 exo/endo selectivity and up to 98% enantiomeric excess have been achieved.

Journal: :Current topics in medicinal chemistry 2014
Carmen Nejera Jose M Sansano

This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.

Journal: :Chemical communications 2014
Javier Adrio Juan C Carretero

Catalytic asymmetric 1,3-dipolar cycloadditions of azomethine ylides have turned out to be one of the most efficient methods for the preparation of enantioenriched pyrrolidines. The past decade has witnessed the development of a bunch of well-defined catalytic systems capable of affording excellent diastereo and enantioselectivities. Recently, a great effort has been focused on expanding the sc...

Journal: :Chemical communications 2011
Naiara Fernández Luisa Carrillo Jose L Vicario Dolores Badía Efraim Reyes

We have developed a highly efficient procedure for carrying out the catalytic enantioselective (3+2) cycloaddition between enals and stable azomethine ylides such as isoquinolinium and phthalizinium methylides. Under the optimized reaction conditions highly substituted chiral pyrroloisoquinolines and pyrrolophthalazines have been obtained in high yields and excellent diastereo- and enantioselec...

2012
Linna Zhou Hironori Ishizaki Michaela Spitzer Kerrie L. Taylor Nicholas D. Temperley Stephen L. Johnson Paul Brear Philippe Gautier Zhiqiang Zeng Amy Mitchell Vikram Narayan Ewan M. McNeil David W. Melton Terry K. Smith Mike Tyers Nicholas J. Westwood E. Elizabeth Patton

Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relative specificity, 5-nitrofurans often cause serious toxic side effects in people. Here, we use yeast and zebrafish, as well as human in vitro systems, to as...

2016
Alexei N Izmest’ev Galina A Gazieva Natalya V Sigay Sergei A Serkov Valentina A Karnoukhova Vadim V Kachala Alexander S Shashkov Igor E Zanin Angelina N Kravchenko Nina N Makhova

An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3'-pyrrolidine-2',3''-indoles]) comprising pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine moieties has been developed. The method relies on a 1,3-dipolar ...

Journal: :Chemical communications 2011
Qing-Hua Li Min-Chao Tong Jun Li Hai-Yan Tao Chun-Jiang Wang

Trifluoromethylated pyrrolidines have been synthesized via catalytic asymmetric 1,3-dipolar cycloaddition with excellent stereoselectivity for the first time. Epimerization of the endo-pyrrolidines obtained from cis-4,4,4-trifluorocrotonate into the exo-pyrrolidines was also revealed.

2014
Rupankar Paira Tarique Anwar Maitreyee Banerjee Yogesh P Bharitkar Shyamal Mondal Sandip Kundu Abhijit Hazra Prakas R Maulik Nirup B Mondal

A new series of pyrrolo[3',4':3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines and pyrrolo[1,2-a]phenanthrolines were efficiently built up from an 8-hydroxyquinoline derivative or phenanthroline via 1,3-dipolar cycloaddition reaction involving non-stabilized azomethine ylides, generated in situ from the parent furo[3,2-h]quinoliniums/phenanthroliums, in presence of a copper(II) chloride-phenant...

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