The origin of 5-HMF (5-hydroxymethyl-2-furaldehyde) in a Shengmaiyin decoction was investigated by the RP-HPLC method below. A C(18) column (250 mm x 4.6 mm, i.d. 5 microm) with a column temperature of 25 degrees C was used. The mobile phase was a mixture of ultra-pure water-acetonitrile (95:5, V/V) and the flow rate was 1.0 ml/min. The detection wavelength was 280 nm. The injection volume was ...

BACKGROUND AND PURPOSE The antioxidant 5-hydroxymethylfurfural (5-HMF) exerts documented beneficial effects in several experimental pathologies and is currently tested as an antisickling drug in clinical trials. In the present study, we examined the cardiovascular effects of 5-HMF and elucidated the mode of action of the drug. EXPERIMENTAL APPROACH The cardiovascular effects of 5-HMF were stu...

Conversion of carbohydrate into 5-hydroxymethylfurfural (5- HMF), a versatile, key renewable platform compound is regarded as an important transformation in biomass-derived carbohydrate chemistry. A variety of ILs, not only acidic but also alkaline ILs, were synthesized and used as catalyst in the production of 5-HMF from disaccharide. Several factors including reaction temperature, IL dosage, ...

The aim of this paper is to evaluate the protective effect of 5-hydroxymethyl-2-furfural (5-HMF) on acute alcohol-induced liver oxidative injury in mice. 5-HMF, a maillard reaction product, was isolated from the fruits of Schisandra chinensis for animal experiments. Experimental ICR mice were pretreated with different doses of 5-HMF (7.5, 15, and 30 mg/kg) for seven days by gavage feeding. Bioc...

BACKGROUND Fructus Corni is derived from the dry ripe sarcocarp of Cornus officinalis Sieb. et Zucc. 5-hydroxymethyl-2-furaldehyde (5-HMF) is an important active composition of the Fructus Corni. However, there have been no reports on the concentration of 5-HMF in freely moving rats using microdialysis coupled with HPLC. MATERIALS AND METHODS The concentration of 5-HMF in free-moving rats aft...

the purpose of this study was to develop a sensitive and fast microdialysis coupled with high-performance liquid chromatographic (hplc) method for determination of 5-hydroxymethyl-2-furaldehyde (5-hmf) in free-moving rats after i.g. administration of the aqueous extract of crud fructus corni and its processed products of jiuzheng pin (jzp). the concentration of 5-hmf in free-moving rats after i...

5-Hydroxymethylfurfural (HMF) is considered to be an important building block for biorefineries and has a high potential for the production of chemicals and fuels. Production of HMF from glucose was studied using phosphoric acid as catalyst, in a water:acetone system with volume ratio of 1:2 and NaCl. An experimental design was applied to examine the influence of temperature, time and concentra...

The conversion of the cellulose into 5-HMF would experience three steps, cellulose to glycose, glycose to fructose and fructose to 5-HMF. Chloride ion can break down the hydrogen bond in cellucose, chromium can catalyze the isomerization of glycose to fructose, and the high temperature is helpful to cyclohydration of fructose to 5-HMF. In this paper, the sawdust has been directly degraded i...

Lignocellulosic biomass is an attractive resource for producing transportation fuels, and consequently novel approaches are being sought for transforming the lignin and cellulosic constituents of biomass to fuels or fuel additives. Glucose, the monomer of cellulose, is a good starting material for exploring such chemistries. We report here the results of an investigation aimed at identifying ca...