Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are used as a first-line treatment in depression. However, many depressed patients are also treated with benzodiazepines to alleviate increased anxiety and sleep disturbances normally associated with depression. Since benzodiazepines inhibit 5-HT neuronal firing activity, they might attenuate SSRI-induced increase in extracellular 5-HT leve...

OBJECTIVE Newer non-benzodiazepines zolpidem and zopiclone ("Z-drugs") are often prescribed instead of benzodiazepine hypnotics, although there is no evidence of differences in effectiveness and safety. Aim was to compare perceptions on benefits and harms of benzodiazepines and Z-drugs between general practitioners (GPs) and community pharmacists (CPs). METHODS A questionnaire was mailed to a...

Are benzodiazepines and anticonvulsants effective for patient with alcohol withdrawal symptoms？(Are anticonvulsants more effective than benzodiazepines？) P: alcohol withdrawal I: benzodiazepines and anticonvulsants C: placebo or active placebo O: prevent or relief alcohol symptoms (ex: delirium, seizure) , prevent re-intake alcohol 關鍵字(Key words): (alcohol withdrawal and benzodiazepine) (alcoho...

ôbjective: the purpose of the present preliminary study was to explore the prevalence of nonmedical abuse of benzodiazepines in a group of opiate-dependent patients who were on methadone maintenance treatment (mmt) program in outpatient clinics in the south-west of tehran, ïran. methods: 114 male and female opiate-dependent clients who met dsm.ïv-tr criteria for opiate dependence with mean age ...

was positive but the rest of tested benzodiazepines were negative. Previous reports2 suggest that there is no cross-reactivity among benzodiazepines. Diazepam is the most similar benzodiazepine to tetrazepam, the only difference between them is the presence at position 5 on the diazepine ring of phenyl in diazepam and clohexen in tetrazepam, and this cyclohexene conformation could explain tetra...

BACKGROUND Over-prescribing of benzodiazepines appears common in many countries, a better understanding of prescribing practices and attitudes may help develop strategies to reduce prescribing. This study aimed to evaluate benzodiazepine prescribing behaviour and attitudes in general practitioners practising in Chiang Mai and Lampoon, Thailand. METHODS Questionnaire survey of general practiti...

Natural and unnatural disasters, beside taking lives, can expose survivors to the risk of developing multiple negative outcomes. Among them, occurrence mental health problems stands out, which require non-pharmacological pharmacological management, with use psychotropic drugs such as antidepressants or benzodiazepines. In this context, review aimed bring together studies that address drugs, and...

OBJECTIVES Recently, more than 63% of the 52,404 drug overdose deaths in the United States involved heroin and opioid pain medications. More than 30% of opioid-related deaths also involved benzodiazepines. Previous studies examining the extent of concurrent opioid and benzodiazepine use have relied on prescription data. To gain fuller insight into the extent of the concurrent use problem, we an...