نتایج جستجو برای: 5-Azacitidin
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Az akut mieloid leukémia kezelésének új lehetőségei: út a személyre szabott terápiás stratégiák felé
Az akut mieloid leukémia (AML) kezelésének arany standardja évtizedek óta az intenzív kemoterápia, azonban erre nem alkalmas vagy refrakter betegeknél jelenleg nincs más kuratív lehetőség. utóbbi évek gyógyszerfejlesztése a jó és rosszabb általános állapotú eseteknél is kibővítette terápiás armamentáriumot, új lehetőségeket kihívásokat teremtve. szerek közé tartozik például venetoclax, IDH1/2 g...
We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite a...
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Nucleotide variants, especially those related to epigenetic functions, provide critical regulatory information beyond simple genomic sequence, and they define cell status in higher organisms. 5-Methylcytosine, which is found in DNA, was until recently the only nucleotide variant studied in terms of epigenetics in eukaryotes. However, 5-methylcytosine has turned out to be just one component of a...
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