the aim of this study was to evaluate the effect of estradiol (e2), oxytocin (ot), relaxin (relaximol) injection and prostaglandin e1 (misoprostol) suppository on the cervix dilation, time of cervical dilation persistency and pregnancy rate of zandi ewes using artificial insemination. eighty 3-4 years old and 55±2.5 kg weight ewes were used for this study. in experiment 1, the ewes were assigne...

BACKGROUND: Compare the efficacy and side effects of misoprostol and methylergometrine for the prevention of postpartum haemorrhage in active management of third stage of labour. METHODS AND METHODS: A prospective study was carried out at SSG Hospital Vadodara from January 2011 to May 2012. 200 women with singleton uncomplicated pregnancies between 37-42 weeks were enrolled for the study. Immed...

Background: The optimal regimen has still to be determined for the use of misoprostol in the surgical termination of pregnancy in the early second trimester. Objective: To compare the outcomes of two different regimens for cervical priming with misoprostol before dilatation and evacuation (D & E) in 13 weeks 16 weeks gestation pregnancy terminations. Methods: A retrospective analysis was perfor...

HPLC method has been described for simultaneous determination of Diclofenac Sodium and Misoprostol in formulation. This method is based on HPLC separation of the two drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 μ) from Germany with isocratic conditions and simple mobile phase containing acetonitrile: water (85: 15) at flow rate of 1 mL/min using UV detection at 220 nm. This method...

BACKGROUND Induction of labor is a major issue in pregnancy management. Finding strategies to increase rate and decrease time to vaginal delivery is an important goal, but maternal or neonatal safety must remain the primary objective. Misoprostol is a synthetic analogue of prostaglandin used off label to ripen the cervix and induce labor. The misoprostol vaginal insert (MVI) was designed to all...

Background: Postpartum hemorrhage is the leading cause of maternal mortality and it's prevention has been identified as key component safe motherhood. Misoprostol an effective uterotonic for prophylaxis control PPH. Aim our study was to evaluate effect preoperative rectal misoprostol (400μg) on blood loss during after cesarean delivery.Methods: It a randomised controlled trial done 200 women sc...

OBJECTIVES To study oxytocin, misoprostol, and methylergometrine in active management of the third stage of labor and determine duration of the third stage of labor, blood loss, adverse effects, and need for additional uterotonics in each group. METHODS Clinical trial of 300 women with healthy singleton pregnancy allocated into three groups to receive either: 10 IU intravenous oxytocin infusi...

Objective: Retrospective analysis and evaluating reliability and efficiency of misoprostol in 87 cases having pregnancy termination by using vaginal misoprostol between 12 and 35 weeks’ gestation. Methods: The present study was conducted at Celal Bayar University, Gynecology and Obstetrics Clinic, Perinatology unit between January 2006 and November 2008. A total of 87 cases at more than 12 week...

background: termination of pregnancy in the second trimester using prostaglandins has been shown to be safe and effective. misoprostol has multiple routes of administration; oral, vaginal, buccal, rectal and sublingual.objective: the study aims to compare the efficacy and safety of intrauterine extra-amniotic and vaginal misoprostol in a dose of 200 microgram every 4 hours for the termination o...

background: intrauterine insemination (iui) is one of the most appropriate and cost-effective methods in infertility treatment. objective: we aimed to investigate effect of vaginal misoprostol on pregnancy rate after iui. materials and methods: two hundred and ten infertile women who were referred to infertility clinic of alzahra hospital by an indication of iui during 2012-2013 were randomly a...