In 1998, Brin and Page [2] identified the need for an Internet search engine capable of scaling to a huge size. They foresaw the explosion of the number of web pages to continue, making human maintained lists of web pages more expensive and less effective. They explain that with this increase in web pages comes an increase in matching pages per query, and thus the ranking system must be more ac...

Cellular automata (CAs) are inherently parallel as the cells evolve in parallel with inter-cell communication restricted to a local neighborhood. The fish and sharks problem from assignment 4 is an example of a 2D CA. In this assignment, we focus on 1D CA where each cell is in one of two states (0 or 1) and its value the next time step depends on the current cell value and the right and left ne...

A growing number of studies have shown that a diet high in long chain SFA and/or obesity cause profound changes to the energy balance centres of the hypothalamus which results in the loss of central leptin and insulin sensitivity. Insensitivity to these important anorexigenic messengers of nutritional status perpetuates the development of both obesity and peripheral insulin insensitivity. A hig...

Lu/BCAM (Lutheran/basal cell-adhesion molecule) is a laminin 511/521 receptor expressed in erythroid and endothelial cells, and in epithelial tissues. The RK573-574 (Arg573-Lys574) motif of the Lu/BCAM cytoplasmic domain interacts with αI-spectrin, the main component of the membrane skeleton in red blood cells. In the present paper we report that Lu/BCAM binds to the non-erythroid αII-spectrin ...

A stable mesoporous blue-emitting MOF NENU-521 was successfully constructed. NENU-521 can serve as a host for encapsulating Alq3 to obtain tunable and efficient white-light emission. The Alq3@NENU-521 composite possesses excellent stability and can be used as a promising white phosphor in WLEDs.

SMTP 521 Reply Code Status of this Memo This memo defines an Experimental Protocol for the Internet community. This memo does not specify an Internet standard of any kind. Discussion and suggestions for improvement are requested. Distribution of this memo is unlimited. Abstract This memo defines a new Simple Mail Transfer Protocol (SMTP) [1] reply code, 521, which one may use to indicate that a...

Canonical transient receptor potential channel 5 (TRPC5) is a nonselective, Ca-permeable cation channel that belongs to the large family of transient receptor potential channels. It is predominantly found in the central nervous system with a high expression density in the hippocampus, the amygdala, and the frontal cortex. Several studies confirm that TRPC5 channels are implicated in the regulat...

UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential for maintaining DNA methylation. uhrf1 mutant zebrafish have global DNA hypomethylation and display embryonic defects, including a small liver, and theydie as larvae.Wemake the surprising finding that, despite their reduced organ size, uhrf1mutants express h...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 3 521–534 www.jcb.org/cgi/doi/10.1083/jcb.200809136 JCB 521 Correspondence to Ronald D. Vale: [email protected] Abbreviations used in this paper: APC, antigen-presenting cell; cSMAC, central SMAC; CTB, cholera toxin subunit B; GPI, glycosylphosphatidylinositol; ITAM, immunoreceptor tyrosine-based activation motif; SMAC, supramol...

Dopamine D4 receptor (DRD4) and serotonin transporter (SERT) gene polymorphisms were studied, as possible genetic risk factors for substance dependence. The case-control study involved a large cohort (n = 362) of healthy Caucasian population, and an initial sample of 73 substance dependent patients (including a subgroup of 53 heroin dependents). Improved methods were applied for genotype detect...