In vitro activities of ABT-492, ciprofloxacin, levofloxacin, trovafloxacin, moxifloxacin, gatifloxacin, and gemifloxacin were compared. ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonf...

The objective of this study was to evaluate the therapeutic safety and efficacy of percutaneous radiofrequency ablation (RFA) with Internally Cooled Electrode for malignant hepatic tumors; which were in contact with blood vessels. A total of 297 patients with malignant hepatic tumors (358 nodules) who underwent RFA, by means of straight Internally Cooled Electrodes, were enrolled in this study....

of a discipline or scientific field by means of counting and analysing the different aspects of written communication, and as such they are considered to be highly useful in the world of research and science in general. They provide valuable information about the research activity of a discipline, country, institution or journal in terms of quantitative indicators (i.e., number of publications,...

The state of pregnancy is known to alter hepatic drug metabolism. Hormones that rise during pregnancy are potentially responsible for the changes. Here we report the effects of prolactin (PRL), placental lactogen (PL), and growth hormone variant (GH-v) on expression of major hepatic cytochromes P450 expression and a potential molecular mechanism underlying CYP2E1 induction by PL. In female huma...

Exchange of macromolecules between the cytoplasm and the nucleus is mediated by dedicated transport channels in the nuclear envelope (NE) called nuclear pore complexes (NPCs). NPCs are embedded within NE at fusion sites between the inner and outer nuclear membrane. They are among the largest macro­ molecular assemblies in eukaryotic cells with an estimated mass of >50 MD (Hetzer et al., 2005; T...

The Wnt signaling pathway controls numerous cell fates in animal development and is also a major cancer pathway. Dishevelled (Dvl) transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domain whose molecular properties and structure are unknown. Here, we demonstrate that the DIX domain of Dvl2 mediates dynamic polymerization, which is essent...

Maternally expressed proteins function in vertebrates to establish the major body axes of the embryo and to establish a pre-pattern that sets the stage for later-acting zygotic signals. This pre-patterning drives the propensity of Xenopus animal cap cells to adopt neural fates under various experimental conditions. Previous studies found that the maternally expressed transcription factor, encod...

* Doctoral Student, The University of Alberta Business School, Edmonton, Canada T6G 2R6. Tel: (780) 492-5435. Fax: (780) 492-3325. E-mail: [email protected]. ** Stephen A. Jarislowsky Distinguished Professor of Finance, School of Business, University of Alberta, Edmonton, Alberta, Canada, T6G 2R6. Tel: (780) 492-5683. Fax: (780) 492 3325. E-mail [email protected]; Research Associate, Nati...

A month ago, Ms. Kolata savagely attacked the new book, OUR STOLEN FUTURE,[2] claiming that "careful studies" (none of which she cited) had "refuted" the premise of the book. (See REHW #486.) OUR STOLEN FUTURE reviewed hundreds of studies published in peer-reviewed journals. The book offers substantial evidence that industrial pollutants may be interfering with the hormones that regulate growth...

Effects of R[+]-8-([1-[3,4-dimethoxyphenyl]-2-hydroxyethyl]amino) -3,7-dihydro-7-[2-methoxyethyl]-1,3-dimethyl-1H-purine-2,6-dione (MKS-492), a reported type III isozyme inhibitor of cyclic nucleotide phosphodiesterase, on antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats were investigated. 1) MKS-492 inhibited antigen-induce...