http://dx.doi.org/10.1016/j.enconman.2014.10.011 0196-8904/ 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). ⇑ Corresponding author. Tel.: +1 585 475 5312; fax: +1 585 475 2510. E-mail addresses: [email protected] (E. Hittinger), [email protected] (T. Wiley), [email protected] (J. Whitacr...

mammalian CNS, the actions of which are regulated by ionotropic glutamate (iGlu) and metabotropic glutamate receptors (mGlu). mGlu receptors are a family of G-protein-coupled receptors comprising eight members, refered to as mGlu1-8. Group I receptors include mGlu1 and mGlu5, which when expressed are coupled via Gq to phospholipase C. Group II (mGlu2 and mGlu3) and group III (mGlu4,6,7,8) recep...

Positive allosteric modulators (PAMs) of a7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of a7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate a7 receptor function, potentially distinguishing effects requiring ion channel currents from signaling induced by nonconducting states. Three small readily reversible ...

Aequorin emits light in the presence of Ca2+, decomposing into apoaequorin, coelenteramide and CO2. Semisynthetic aequorins, produced by replacing the coelenterazine moiety in aequorin with analogues of coelenterazine, showed widely different sensitivities to Ca2+ as well as certain spectral variations. A group of semisynthetic aequorins, e-type aequorins, showed bimodal luminescence, with peak...

This study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A) in 49 healthy Japanese subjects aged 22–58 years using endogenous cortisol 6b-hydroxylation clearance [CLm(6b)], a novel biomarker for CYP3A phenotyping. CLm(6b) in the 49 healthy subjects was 2.40 6 0.79 ml/min with an approximately 4fold interindividual variability of CYP3A activity. The mean clearance in t...

and Applied Analysis 3 2. Lemmas In order to establish ourmain result, we need several formulas and lemmas, whichwe present in this section. The following formulas were presented in 10, Appendix E, pages 474-475 : Let r ∈ 0, 1 , then