3-Methylcholanthrene (MC) is a readily metabolized aryl hydrocarbon receptor (AHR) agonist. MC disrupts expression of mouse hepatic growth hormone (GH) signaling components and suppresses cytochrome P450 2D9 (Cyp2d9), a male-specific gene controlled by pulsatile GH via signal transducer and activator of transcription 5b (STAT5b). To determine if these effects of MC depend on hepatic microsomal ...

Unraveling the mechanisms underlying early neural differentiation of embryonic stem cells (ESCs) is crucial to developing cell-based therapies of neurodegenerative diseases. Neural fate acquisition is proposed to be controlled by a ‘default’ mechanism, for which the molecular regulation is not well understood. In this study, we investigated the functional roles of Mediator Med23 in pluripotency...

Roughly, this class will be about studying one fundamental object in two different guises. Let X be an algebraic curve over a field k, and let G be some algebraic group over X . We assume for this lecture that G splits trivially as G0 ×X , but this is not necessary for what we will do in the course. The fundamental object we will study is the collection of G-bundles on X . We will consider two ...

Example. Every non-zero element of ⋀ V is trivially totally decomposable. Example. If dimV = 3, then every non-zero element of ⋀ V is totally decomposable. Proof. Given a sum v1 ∧v2 +v3 ∧v4 of two non-zero elements of ⋀ V , the two-dimensional subspaces Span(v1, v2) and Span(v3, v4) must intersect. If w1 is in the intersection, then we can rewrite v1∧v2 = w1 ∧w2 for some w1 ∈ Span(v1, v2). Simi...

Laser-based illuminant has been a topic of increasing interest in recent years and both color quality blue light hazards are the key issues that need to be addressed. In this paper, performances hazard were investigated by comparing 465 nm laser-excited phosphor materials traditional 452 respectively. Phosphor-converted laser-based (pc-LBI) consisting 465-nm 635-nm LDs (LBI-465) rendering index...

Background: In Tanzania elders are respected as repositories of inherited wisdom, experienced and principal decision makers in the community. However, evidence shows that such repositories are no longer considered important in most societies. As a result elders are neglected with some mistreatment in terms of provision of health and social services for instance; at times they get denied and ign...