Disorders of sex development (DSD) are congenital conditions characterized by atypical development of chromosomal, gonadal, and phenotypic sex. 46, XY DSD can result from disorders of testicular development or disorders of androgen synthesis/action. Prophylactic gonadectomy should be considered in patients with 46, XY DSD because of the increased risk of gonadal malignancy. We report two rare c...

2014 The role of interplanar fluctuations associated with « parallel » vortex loops is considered in the two coupled problems of XY magnetism and superconductivity of the second kind, in a quasitwodimensional situation. Using an admittedly simplified criterion, it is argued that, for weak interplanar couplings, the critical 3d temperature is related to the multiplication of such loops ; it shou...

INTRODUCTION We examine a presumptive case of complete androgen insensitivity syndrome (CAIS) with certain unusual features. CLINICAL PICTURE A woman with early onset osteoporosis gave a history of primary amenorrhoea and surgery for intraabdominal gonads. She subsequently defaulted follow-up and hormone replacement therapy. Endocrinological evaluation revealed hypergonadotrophic hypogonadism...

Sexual ambiguity commonly known as intersexuality, is a condition of imperfect sexual differentiation between male and female. The present study was aimed at analyzing the chromosomal abnormalities of intersex subjects in Coimbatore city, India Of the 30 intersex cases studied, 10 of them were genetically male (46,XY) but phenotypically females, 8 of them were genetically female (46,XX) with ma...

Background: Disorders of sex development (DSD) are a medical condition that affects the normal process of sexual  Various of the genes needed for gonad development have been identified by investigation of patients with disorders sex development (DSD).Phenotypes of patients with 46,XY DSD range from atonalism in female phenotype with complete external  genitalia to male phenotype with testicular...

Gonadal dysgenesis resulting in primary infertility is one of the most common features of Turner syndrome. There have been a number of cases described of pregnancy in 45,X subjects, but whether or not the fertility is associated with a 46,XX cell line in the germ cells is not known. We describe a 45,X/46,X,psu idic(Xq) female with normal fertility, in whom a cryptic 46,XX cell line was found in...

Two commentaries explore the question of how much information should be disclosed to a 16-year-old female patient about the genetic abnormality, testicular feminization (XY genotype), which renders her infertile. She has presented with precancerous testes that require surgical removal and also needs an operation on her vagina in order for her to be able to engage in intercourse. Minoque and T...