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The disposition of ertugliflozin (PF-04971729), an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [C]-ertugliflozin to healthy human subjects. Mass balance was achieved with approximately 91% of the administered dose recovered in urine and feces. The total administered radioactivity excreted in feces and urine was...

The prevalence of obesity in pregnancy is rising exponentially; about 15–20% of pregnant women now enter pregnancy with a BMI which would define them as obese. This paper provides a review of the strong links between obesity and adverse pregnancy outcome which operate across a range of pregnancy complications. For example, obesity is associated with an increased risk of maternal mortality, gest...

verbally-mediated’ representations, instead of ‘image-based’ ones (Noppeney and Price, 2004). Performance on the Wisconsin Card Sorting Test has been correlated with activation in the dorsolateral prefrontal cortex (Nagahama et al., 1996). Performance on the Delis-Kaplan Executive Function System has also been correlated with left frontal lobe volume (Fine et al., 2009), as has a total abstract...

A defining feature of glial cells has been their inability to generate action potentials. We show here that there are two distinct types of morphologically identical oligodendrocyte precursor glial cells (OPCs) in situ in rat CNS white matter. One type expresses voltage-gated sodium and potassium channels, generates action potentials when depolarized and senses its environment by receiving exci...

Southern African countries have a good cultural tourism development potential, and many countries in the region have identifi ed the development of cultural tourism as one of the key growth areas in tourism. A specifi c element of cultural tourism is based on crafts that are sold for visitors in various sites and market places. Crafts and craft markets are relatively visible in the Southern Afr...

This study was conducted to evaluate retrospectively 203 patients diagnosed with hydatid cyst disease and treated surgically at two university medical centers between 1999 and 2009 in Tehran, the capital of Iran. Cystic echinococcosis (CE) affected more females 117 (57.6%) than males 86 (42.4%). A remarkable gender difference skewed towards females was observed, and the male/female ratio among ...

Inclusive business is described as private sector-led business initiatives that aim to profi tably engage low-income populations across productive value chains. Th is paper aims to quantify the impact of businesses implementing inclusive business strategies to determine the value to local communities as well as the tourism business. Th e research reviews the direct impact of the business on com...