The pathogenesis of chronic inflammatory diseases, including rheumatoid arthritis, is regulated, at least in part, by modulation of oxidation-reduction (redox) homeostasis and the expression of redox-sensitive inflammatory genes including adhesion molecules, chemokines, and cytokines. AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethyl...

Agrocampus Ouest, Centre d’Angers, UMR 1345 IRHS (Agrocampus Ouest, INRA, Université d’Angers), SFR QUASAV 4207, 2 rue Le Nôtre, 49045 Angers Cedex 01, France b INRA, UMR 1345 IRHS (Agrocampus Ouest, INRA, Université d’Angers), SFR QUASAV 4207, 42 rue Georges Morel, 49071 Beaucouzé, France University of Fribourg, Department of Biology, Plant Biology, Chemin du Musée 10, 1700 Fribourg, Switzerla...

miR-1271 is a multifunctional post-translational modulator, which is involved in several diseases. However, the association between microRNA (miR)‑1271 and fibronectin 1 (FN1) remains to be fully elucidated in neuroglioma. In the present study, it was hypothesized that a post‑translational mechanism of miR‑1271 regulates the expression of FN1 in the progression of neuroglioma. The present study...

in this study, a complex crop model was developed that integrates the various components of swap and csm-ceres-maize (dssat v4.0) model with the purpose of developing a more efficient model and according to the internal requirements. in the hybrid model, ceres-maize supplies swap model with daily leaf area index and root depth and on the other hand swap model supplies ceres-maize with daily wea...

OBJECTIVE Endometrial carcinoma (EC) is one of the most common female malignancies worldwide. Growing evidence showed that microRNAs (miRNAs) are involved in the EC progression. The present study aimed to investigate the role of miR-1271 in the development and progression of EC. PATIENTS AND METHODS The EC tissues and adjacent normal tissues were obtained from 42 EC patients. The expression o...

BACKGROUND Ovarian cancer is the most lethal gynecological malignant cancer in the female genital system. The dysfunction of miRNA contributes to ovarian cancer development. MATERIAL AND METHODS The miR-1271 level in ovarian cancer tissues and cells was assayed by qRT-PCR. The miR-1271 expression in cells was overexpressed by miRNA-mimic transfection and reduced by miRNA-antisense-oligonucleo...

The aim of the current study was to investigate the expression and role of microRNA (miR)-1271 in the pathogenesis of osteosarcoma, and the associated underlying mechanisms. Tissue samples from 45 patients with osteosarcoma were collected, while the 143B, MG-63 and U-2 OS osteosarcoma cell lines were also cultured. The expression levels of miR-1271 in the tissues and cells were detected with re...

Recent deep-sequencing efforts have identified many novel non-conserved small RNAs that are expressed at low levels in certain mammalian cells. Whether these small RNAs are important for mammalian physiology is debatable, therefore we explored the function of one such RNA, human miR-1271. This small RNA is similar in sequence to miR-96, a highly conserved microRNA that when mutated causes heari...

Numerous studies showed that drug resistance of gastric cancer cells could be modulated by the abnormal expression of microRNAs (miRNAs) which target multiple cell signaling pathways. The possible function of miR-1271 in the formation of cisplatin resistance in gastric cancer cells has been investigated in this study. miR-1271 was significantly down-regulated in gastric cancer tissues and vario...