By tracking conformational transitions of individual ion channel proteins, single-channel recordings allow the observer to deduce gating mechanisms, as well as estimate rate constants of microscopic gating steps. For most ion channels, gating mechanisms are complex, comprising multiple stable open (O) and closed (C) conformations among which conformational transitions may follow a network of po...

The pregnane X receptor (PXR) has been postulated to play a role in the metabolism of a-tocopherol owing to the up-regulation of hepatic cytochrome P450 (P450) 3A in human cell lines and murine models after a-tocopherol treatment. However, in vivo studies confirming the role of PXR in a-tocopherol metabolism in humans presents significant difficulties and has not been performed. PXR-humanized (...

By tracking conformational transitions of individual ion channel proteins, single-channel recordings allow the observer to deduce gating mechanisms, as well as estimate rate constants of microscopic gating steps. For most ion channels, gating mechanisms are complex, comprising multiple stable open (O) and closed (C) conformations among which conformational transitions may follow a network of po...

In the present study, a total of 137 blood samples were collected from cattle and water buffaloes in central region of Vietnam and tested using nested polymerase chain reaction (nPCR), enzyme-linked immunosorbent assay (ELISA) and indirect fluorescent antibody test (IFAT) to determine the molecular and serological prevalence of Babesia bovis and Babesia bigemina. In cattle, the prevalence of B....

By tracking conformational transitions of individual ion channel proteins, single-channel recordings allow the observer to deduce gating mechanisms, as well as estimate rate constants of microscopic gating steps. For most ion channels, gating mechanisms are complex, comprising multiple stable open (O) and closed (C) conformations among which conformational transitions may follow a network of po...

By tracking conformational transitions of individual ion channel proteins, single-channel recordings allow the observer to deduce gating mechanisms, as well as estimate rate constants of microscopic gating steps. For most ion channels, gating mechanisms are complex, comprising multiple stable open (O) and closed (C) conformations among which conformational transitions may follow a network of po...

By tracking conformational transitions of individual ion channel proteins, single-channel recordings allow the observer to deduce gating mechanisms, as well as estimate rate constants of microscopic gating steps. For most ion channels, gating mechanisms are complex, comprising multiple stable open (O) and closed (C) conformations among which conformational transitions may follow a network of po...

– We analyzed skins and skulls of chevrotains (Moschiola sp., Artiodactyla) from Sri Lanka and India, and found considerable differences within this taxon. Based on the consistency of these differences we concluded that this taxon can be divided into three species: Moschiola indica from southern India, M. meminna from the Dry Zone in Sri Lanka, and M. kathygre n. sp. from Sri Lanka’s Wet Zone. ...

1.1.2 What is randomness? Successive observations, x(n-1), x(n), x(n+1), ... are dependent on one another • If x(n) can be predicted exactly from the previous samples then the time-series signal is deterministic • If x(n) cannot be predicted exactly from the previous samples the time-series signal is random or stochastic • If x(n) is independent from previous samples then the time-series signal...