BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. BHLHE40/41 were recently shown to be involved in an epithelial-to-mesenchymal transition (EMT). However, the precise mechanism of EMT control by BHLHE40/41 remains unclear. In the present study, we demonstrated that BHLHE40/41 expression was controlled in a path...

Proper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, heat stress (HS) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of HS on whole-body insulin sensitivity. Female pigs (57 ± 4 kg body weight) were subjected to two experimental periods. During period 1, all pi...

OBJECTIVE The potential insulin-sensitizing function of angiotensin II type 1 receptor blockade (ARB) with regard to selected adipokines is not fully explained so far. Our study aimed to explore the influence of acute hyperinsulinaemia and acutely induced ARB on resistin and adiponectin concentrations and expressions in healthy subjects. DESIGN AND METHODS Plasma adipokines were measured: 1) ...

Andy Clark and David Chalmers argue that the mind sometimes extends outside the body to encompass features of the environment (HEC). HEC has been criticised by Fred Adams, Kenneth Aizawa, and Robert Rupert. In this paper, I argue for two claims: (1) HEC is a harder target than those critics have supposed; HEC is entailed by functionalism, a commonly held view in philosophy of mind, and one to w...

The last few years have witnessed an enormous study in the area of integrated hydrological modeling with GIS application. In this research, attempt was made to critically look at the application of HEC-GeoHMS which is an extension of ArcView in HEC-HMS; an HEC package which is a new generation of software being developed for rainfall-runoff simulation. The main role of HEC-GeoHMS is to formulat...

Reduced intrahepatic nitric oxide (NO) bioavailability and increased cyclooxygenase-1 (COX-1)-derived vasoconstrictor prostanoids modulate the hepatic vascular tone in cirrhosis. We aimed at investigating the reciprocal interactions between NO and COX in the hepatic endothelium of control and cirrhotic rats. NO bioavailability (DAF-FM-DA staining), superoxide (O(2)(-)) content (DHE staining), p...

In this work, we present new insights related to a debate on the morphological structure of hydroxyethyl cellulose (HEC) molecules when dissolved in water, i.e., whether HEC adopts a linear-flexible or a rod-like fibrillar configuration. We have employed “seven” rheological techniques to explore the viscoelastic properties of HEC solutions at different time and length scales. This work demonstr...

Real-time applications usually not only have a certain Packet Loss Ratio (PLR) requirement but also can have strict delay constraints. In the past, we proposed a Hybrid Error Correction (HEC) scheme with Packet Repetition (PR) technique for guaranteeing a certain PLR requirement under strict delay constraints. Unfortunately, the HEC-PR scheme can only work efficiently in multicast scenarios wit...

INTRODUCTION Few studies have described the inequalities in hormonal emergency contraception (HEC) use in developing countries. Thus, the main aim of this manuscript is to study socio-demographic inequalities in HEC use among Nicaraguan women, and to study if inequalities in HEC use arise from exposure to different forms of intimate partner violence (IPV). METHODS Data from a national cross-s...

In this paper, based on an ethnographic study, we show how management controllers craft their jobs through their daily practice and try to stretch their occupational identity. We adopt an original posture, developing a ‘negative ontology’ of practice, identity at work and professional competition. We argue that studying what individuals hide or despise in their daily activities enriches our und...