نتایج جستجو برای: 4-Dihydropyrimidinone

تعداد نتایج: 1303651  

2012
Uttara Soumyanarayanan Varadaraj G Bhat Sidhartha S Kar Jesil A Mathew

Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship...

2012
Abdelmadjid Debache Louisa Chouguiat Raouf Boulcina Bertrand Carboni

The synthesis of various substituted Biginelli 3,4-dihydropyrimidinone/thione and Hantzsch 1,4dihydropyridine derivatives has been achieved using a modified procedure in the presence of potassium ter-butoxide (tBuOK) as a catalyst under solvent-free conditions, in good to excellent yields.

2013
Anjna Bhatewara Srinivasa Rao Jetti Tanuja Kadre Pradeep Paliwal Shubha Jain

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antiba...

2016
Basavaiah Umesha Yeriyur Basavaiah Basavaraju

A series of chalcones, dihydropyrimidinone and dihydropyrimidinethione derivatives were synthesized in good yields by Claisen Schmidt reaction of acetophenones with substituted aldehydes in the presence of sodium hydroxide in water-ethanol mixture followed by the condensation reaction of chalcones with urea and thiourea in ethanol respectively. The structures of the synthesized compounds were e...

Journal: :Materials advances 2021

Carbon quantum dots have been conjugated with medicinal dihydropyrimidinone molecules to formulate a multifunctional anticancer drug. Benign CQDs impart fluorescence properties, which enable the composite be used for bioimaging.

Journal: :Chemical communications 2015
Maria Strocchia Stefania Terracciano Maria G Chini Antonio Vassallo Maria C Vaccaro Fabrizio Dal Piaz Antonietta Leone Raffaele Riccio Ines Bruno Giuseppe Bifulco

Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.

2012
Vivekanand B. Jadhav Harish V. Holla Sunil U. Tekale Rajendra P. Pawar

The Biginelli reaction, which is a three-component reaction for the synthesis of dihydropyrimidinone and corresponding dihydropyrimidinethiones (DHPMs) is known for more than a century. A large number researchers have shown consistent attention towards the study of Biginelli reaction, leading towards structurally diversified molecular libraries of DHPMs and it’s analogues, having significant bi...

2011
Bruno Piqani Wei Zhang

Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind-Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency...

2009
Hamid Reza Memarian Asadollah Farhadi

A new facile cost-effective method for the oxidation of acetyl and carboethoxy derivatives of 3,4dihydropyrimidin-2(1H)-ones (DHPMs) by using potassium peroxydisulfate in water as solvent under microwave irradiation has been developed. Whereas the presence of the acetyl group instead of the carboethoxy group in position 5 decreases the rate of oxidation, the nature of the additional subtituent ...

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