نتایج جستجو برای: 36.3

تعداد نتایج: 4130  

2002
ANNE ELLAWAY STUART WOOD SALLY MACINTYRE

Background. There are many reasons why people frequently consult their general practitioner (GP). Although loneliness is increasingly recognized as a problem affecting wellbeing for elderly people, it has rarely been addressed as a predictor of frequency of consultation. Aim. To examine whether loneliness is associated with rates of GP consultations (home and surgery visits). Method. Analysis o...

2011
So Young Yoo Woo-Jae Chung Tae Hyun Kim Mimi Le Seung-Wuk Lee

Fabrication of precisely designed active biomaterials is of great interest in many areas of bionanotechnology including regenerative medicine, drug screening, and biosensors. Microand nanometre scale defined patterns have been developed which can control the spacing and density of signaling molecules through top-down microfabrication approaches, such as photolithography, e-beam lithography, and...

2014
Pierre-Marie Le Droguen Sandra Claret Antoine Guichet Véronique Brodu

Epithelial remodelling is an essential mechanism for organogenesis, during which cells change shape and position while maintaining contact with each other. Adherens junctions (AJs) mediate stable intercellular cohesion but must be actively reorganised to allow morphogenesis. Vesicle trafficking and the microtubule (MT) cytoskeleton contribute to regulating AJs but their interrelationship remain...

2017
Yahong Wang Ting Chen Haili Huang Yun Jiang Lawei Yang Ziying Lin Huijuan He Tie Liu Bin Wu Jie Chen David W. Kamp Gang Liu

Increasing evidence suggests that microRNAs play key roles in lung cancer. Our previous study demonstrated that microRNA 363-3p (miR-363-3p) is downregulated in lung cancer tissues. In this study, we demonstrated that overexpression of miR-363-3p inhibits the proliferation and colony formation of A549 and H441 cells, while silencing of miR-363-3p has the converse effects. The anti-oncogenic fun...

Journal: :Pediatric Critical Care Medicine 2018

2015
Bo Song Jin Yan Chao Liu Haiyang Zhou Yangchun Zheng

BACKGROUND Gastric cancer (GC) is the most common cancer in the world. Despite the advancement of the treatment of GC, the 5-year overall survival rate is still very low. MicroRNAs (miRNAs) play important roles in the pathogenesis of GC. A recent study suggested that miR-363-3p plays a role in the development of GC. However, the function of miR-363-3p in GC is not fully understood. MATERIAL AND...

2013
Bruce A. Maxwell

Course Description Robotics addresses the problems of controlling and motivating mechanical devices to act intelligently in dynamic, unpredictable environments. Major topics will include: navigation and control, mapping and localization, robot perception using vision and sonar, kinematics and inverse kinematics, and robot simulation environments. To demonstrate these concepts we will be using m...

2017
Yang Lin Tianmin Xu Shunqing Zhou Manhua Cui

In this study, we investigated the role of microRNA-363(miR-363) in ovarian cancer (OC) progression. MiR-363expression was downregulated in OC patient tissues and four OC cell lines (SKOV3, A2780, OVCAR and HO-8910). Low miR-363 levels were associated with advanced stage, lymph node metastasis, and poor prognosis in OC. MiR-363 overexpression decreased growth, colony formation, migration and in...

2014
Vanessa Garcia Stéphane Aris-Brosou Joel Dudley

Although efficient influenza vaccines are designed on a regular basis, the only protection of human populations against an unforeseen virus such as during the H1N1 pandemic in 2009 might be antiviral drugs. Adamantanes and neuraminidase inhibitors (Oseltamivir) represent two classes of such drugs that target the viral matrix protein 2 and neuraminidase, respectively. Although the emergence of r...

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