The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

The tension between public health and individual rights raises key questions in the face of public health crises such as tuberculosis (TB) and Ebola: What are the circumstances that warrant the obligatory detention of individuals with an infectious disease as a measure of protecting the general public?1 What are the implications for the protection of privacy while managing and controlling the s...

People engage in multiple types of information-seeking strategies within an information-seeking episode. The objective of this pilot study is to investigate search moves and tactics made by end-users when searching for visual information. The pilot study involves 5 undergraduate students from the Department of Journalism and Media Studies at Rutgers University using the AccuNet/AP Photo Archive...

Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca signaling pathways and, as such, are emerging novel therapeutic and insecticidal targets. RyRs are so named because they bind the plant alkaloid ryanodine with high affinity and although it is established that ryanodine produces profound changes in all aspects of function, our understanding of the mechan...

Despite of the fact that a large variety of stochastic structural analysis methods have been developed during the last years, these methods are still not fully accepted by practicing engineers in the industry (see e.g. Székely et al. 1998). One of the key issues of software development for stochastic structural analysis is therefore to bridge the gap between research results and engineering pra...

Nutritional assessment and dietary advice are fundamental to inflammatory bowel disease (IBD) patient management and all patients should have access to a dietitian. Newly diagnosed patients often think that their pre-illness diet has contributed to the development of their IBD. However, epidemiological evidence to support diet as a risk factor is lacking. How the diet contributes to the gastroi...

High amounts of time spent sedentary and low levels of physical activity have been implicated in the process of excessive adiposity gains in youth. The aim of this review is to discuss the role of physical activity, sedentary time and behaviour (i.e. television (TV)-viewing) in relation to adiposity during the first two decades of life with a specific focus on whether the association between se...

Eighteen day old neonate presented with features of early neonatal sepsis. History of mother revealed a travel from non-endemic area of malaria to endemic area, and on the 7th gestational age mother detected as having malaria. She was treated with quinine and cured. Baby was also evaluated for congenital malaria in first few neonatal days and discharged. Now the baby on evaluation shows anemia,...

1 Department of Neurology, University Hospital Zurich, 8091 Zurich, Switzerland 2 Division of Neuropsychology, Institute of Psychology, University of Zurich, 8050 Zurich, Switzerland 3 Department of Psychiatry, University Hospital Zurich, 8091 Zurich, Switzerland 4 Institute for Biomedical Engineering, University and ETH Zurich, 8091 Zurich, Switzerland 5 Zurich Centre for Integrative Human Phy...