GSK1322322 (N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl) hydrazinyl)-3-oxopropyl)-N-hydroxy-formamide) is an antibiotic in development by GlaxoSmithKline. In this study, we investigated the metabolism and disposition of [C]GSK1322322 in healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel...

Queen Helen Nemanjić (?–Brnjaci near Zubin Potok, February 8, 1314) was a Serbian medieval queen and consort of King Stefan Uroš I (r. 1243–1276), the fifth ruler Nemanide dynasty. She mother kings Dragutin II Milutin. Today, she is known as Anjou (Jelena Anžujska in Serbian) although her real name most probably Heleni Angelina (Ελένη Aγγελίνα). founder Orthodox monastery Gradac well four Franc...

BACKGROUND Data on nutritional status and correlates of noncommunicable diseases are scarce for resource-poor settings in sub-Saharan countries. With the scope of a project, "Access to Food and Nutrition Status of the Zanzibari Population," data for investigating public health questions were collected using proven measurement and laboratory standards. OBJECTIVE The present study aims at provi...

The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. Themouse neural plate is a simple epithelium that is transformed into a columnar pseudostratified tube over the course of ∼24 h. Apical F-actin is known to be important for neural tube closure, but the precise roles of actin dynamics in t...

Electronic sensor array coupled with artificial neural network for detection of Salmonella Typhimurium Ubonrat Siripatrawan a,∗, John E. Linz b, Bruce R. Harte c a Department of Food Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand b Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824-1314, USA c School of Packaging,...

Objectives: Ultrasonic rates of fetal malformation and prenatal soft-marker positivity in Mongolian and Han populations were investigated through a standardized screening protocol. Methods: A retrospective study of 7753 pregnancies (Mongolian, 1314; Han, 5751; others, 688) was conducted in our hospital, examining prenatal fetal ultrasound tests performed between September, 2011 and February, 20...