W. van Dorp1,2,*, M.M. van den Heuvel-Eibrink2, A.C.H. de Vries2, S.M.F. Pluijm2, J.A. Visser3, R. Pieters2, and J.S.E. Laven1 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC-University Medical Centre Rotterdam’s– Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Dr....

1 Department of Neurology, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands 2 Department of Internal Medicine, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands 3 Department of Pathology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 4 Department of Clinical Genetics, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands 5 DZNE, Germ...

The mechanisms underlying neurodegeneration and loss of dopaminergic signalling in Parkinson’s disease are still only partially understood. Phosphodiesterase 10A (PDE10A) is a basal ganglia expressed dual substrate enzyme, which regulates cAMP and cGMP signalling cascades, thus having a key role in the regulation of dopaminergic signalling in striatal pathways, and in promoting neuronal surviva...

The maturation of iron–sulfur (Fe/S) proteins in eukaryotes has been intensively studied in yeast. Hardly anything is known so far about the process in higher eukaryotes, even though the high conservation of the yeast maturation components in most Eukarya suggests similar mechanisms. Here, we developed a cell culture model in which the RNA interference (RNAi) technology was used to deplete a po...

Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India Department of Medical Microbiology & Infectious Diseases, Erasmus University Medical Centre 3015 CE, Rotterdam, The Netherlands For correspondence: Dr John P. Hays, Room L-247, Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, 3015 CE, Rot...

Department of Immunobiology, Biomedical Primate Research Center, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands Department Immunology, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands Center for Research and Care in MS, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands Department of Molecular Cell Biology and Immunology, Vrije U...

Enrico Rossi, Brendan M. McQuillan, Joseph Hung, Peter L. Thompson, Conchita Kuek and Asymptomatic Carotid Atherosclerosis in a Community Population Serum Ferritin and C282Y Mutation of the Hemochromatosis Gene as Predictors of Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272...

1 Hyperinsulinemia in the Metabolic Syndrome 2 Francesca Schinzari; Manfredi Tesauro; Valentina Rovella; Nicola Di Daniele; Paolo 3 Gentileschi; Nadia Mores; Umberto Campia; Carmine Cardillo 4 5 Affiliation 6 From the Departments of Internal Medicine and Pharmacology, Catholic University 7 Medical School, Rome, Italy; Departments of Internal Medicine and Surgery, 8 University of Tor Vergata, Ro...