Human cytochromes P450 (P450s) play a major role in the biotransformation of drugs. The generated metabolites are important for pharmaceutical, medical, and biotechnological applications and can be used for derivatization or toxicological studies. The availability of human drug metabolites is restricted and alternative ways of production are requested. For this, microbial P450s turned out to be...

Identifying Population Groups at High Risk of Social Exclusion: Evidence from the ECHP In recent years in the public discourse of many European countries there has been a shift in emphasis from “poverty” to “social exclusion”. Broadly interpreted, “social exclusion” implies the “inability of an individual to participate in the basic political, economic and social functionings of the society in ...

GENERIC NAME PAGE Amitriptyline 389 Amoxapine 389 Bupropion 388 Carbamazepine 395 Citalopram 388 Clomipramine 389 Desipramine 389 Doxepin 389 Fluoxetine 387 Fluvoxamine 386 Imipramine 389 Isocarboxazid 392 Lithium 393 Maprotiline 389 GENERIC NAME PAGE Mirtazapine 388 Nefazodone 389 Nortriptyline 389 Olanzapine 395 Paroxetine 388 Phenelzine 392 Protriptyline 389 Sertraline 387 Tranylcypromine 39...

BACKGROUND External laryngeal trauma (ELT) is a rare but clinically important injury. OBJECTIVE To perform the first population-based, time series analysis of the epidemiology, management, and outcomes of ELT using an 11-state, inpatient sample database containing more than 54 million patients. PATIENTS Three hundred ninety-two patients with a primary or secondary diagnosis of ELT were iden...

Copepod growth rates were estimated from shipboard measurements of egg production of adult female Calanus agulhensis, Calanoides carinatus, Nannocalanus minor, and Centropages brachiatus and molting rates of juvenile stages (N6–C5) of C. agulhensis. Data were obtained during austral spring and summer of 1989–1995 in the southern Benguela upwelling system. While maximum growth rates showed less ...

Specifically accessible chromatin sites, detected as DNase I hypersensitive sites (DNase I HSs), have been found at promoters of most genes in yeast, human as well as in Arabidopsis chromatin. The DNase I HSs are constitutively present at promoters of most genes both at inactive and activated states. On the other hand, appearance and disappearance of DNase I HSs have been observed at several de...

Objective: To review the research literature published within the past 10 years regarding the impact of media on children and adolescents. Method: Media categories researched with computer technology included television and movies, rock music and music videos, advertising, video games, and computers and the Internet. Results: Research prior to 1990 documented that children learn behaviors and h...