We describe the design issues in an implementation of the ESA/390 architecture based on binary translation to a very long instruction word (VLIW) processor. During binary translation, complex ESA/390 instructions are decomposed into instruction \primitives" which are then scheduled onto a wide-issue machine. The aim is to achieve high instruction level parallelism due to the increased schedulin...

long-term sequelae such as thyroid dysfunction, systemic lupus erythematosus, etc.1 Methods: We report a 39 year old female with history of traumatic brain injury (TBI) received proflaxis with phenytoin sodium 100 mg 1vo c/8 hours, 4 weeks after starting with fever, malaise, sore throat, cervical lymphadenopathy, appeared itchy rash in face, neck. Admitted with malaise, generalized rash, edema ...

RNA interference (RNAi) is a powerful tool to study gene function in cultured cells. Transfected cell microarrays in principle allow high-throughput phenotypic analysis after gene knockdown by microscopy. But bottlenecks in imaging and data analysis have limited such high-content screens to endpoint assays in fixed cells and determination of global parameters such as viability. Here we have ove...

This review reappraises dietary advice to reduce and replace SFA for the prevention of CVD. In the 1970s, SFA accounted for about 18% UK food energy, by 2001 it had fallen to 13% and continues to be above the <11% target. Compared with carbohydrates, C12–C16 SFA raise serum total cholesterol (TC), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) without affecting the TC:HDL-C ratio; other SF...

The technical, business, and market requirements for large enterprise servers (“mainframes”) strongly influence the design of microprocessors for these systems. Specific characteristics of the ESA/390 and z/Architecture instruction set architectures lead to different pipeline and branch prediction strategies than are found in most other microprocessors. The requirements for robust, scalable per...

Results of minimal inhibitory concentration tests with a diversity of bacterial strains showed that 9-chloro-9-(4-diethylaminophenyl)-10-phenylacridan (C-390) inhibited the growth of all microorganisms tested (other than Pseudomonas aeruginosa) at 25 microgram/ml or less, whereas MICs obtained for P. aeruginosa ranged from to to greater than 100 microgram/ml. Therefore, C-390 was evaluated as a...

This paper describes the author’s experiences in performance management and capacity planning for Oracle applications on OS/390 mainframes. The special performance considerations and problems in mainframe Oracle implementations are covered, together with the ways in which those systems can be configured for optimum performance. A real-life case study is used to illustrate the required data sour...

To improve the modeling and simulation of pharmacokinetics in pediatric patients, research into developmental and disease-specific determinants is needed. This article describes the evaluation of the activity of in vitro cytochrome P450 (P450), an important enzyme family in drug metabolism, in children with hepatic dysfunction. The activity of six P450 isoforms (CYP1A2, 2C9, 2C19, 2D6, 2E1, and...