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Sensory stimuli trigger complex patterns of neuronal action potentials in the brain. Measurement of these patterns is important for understanding the way the brain processes information. There are currently no efficient techniques to visualize patterns of highfrequency action potentials. Because individual action potentials result in transient increases in intracellular Ca2+, fluorescent calciu...
Cynomolgus monkeys are a commonly used species in preclinical drug discovery, and have high genetic similarity to humans, especially for the drug-metabolizing cytochrome P450s. However, species differences are frequently observed in the metabolism of drugs between cynomolgus monkeys and humans, and delineating these differences requires expressed CYPs. Toward this end, cynomolgus monkey CYP3A4 ...
Applications Submission date: July 31, 2002 Word count: 6633 + (3 figures) * 250 words/figure = 7383 Michael Mahut, INRO Consultants, Inc., 5160 Decarie Blvd. Suite 610, Montreal H3X 2H9, Canada. Telephone: (514) 369-2023; fax: (514) 369-2026; e-mail: [email protected] Michael Florian, University of Montreal, P.O. box 6120, station centre-ville, Montreal H3C 3J7, Canada; and INRO Consultants, In...
Noncoding microRNAs inhibit translation and lower the transcript stability of coding mRNA, however miR-369 s, in aberrant silencing genomic regions, stabilizes target proteins under cellular stress. We found that in vitro differentiation of embryonic stem cells led to chromatin methylation of histone H3K4 at the miR-369 region on chromosome 12qF in mice, which is expressed in embryonic cells an...
http://www.sciencemag.org/cgi/content/full/317/5836/369 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/317/5836/369/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
Production and Physicochemical Characteristics.................................. 368 Rabbits.................................................................. 368 Guinea pigs............................................................... 369 Mice................................................................... 369 Rats................................................................... 370 Pou...
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