Schistosomiasis is widespread, especially in Asia, Africa and Latin America (IARC, 1994, Ross et al., 2002). A report of the World Health Organization in 1993 estimated that 200 million people were infected with schistosomes and that 600 million people were at risk of infection in 74 countries (WHO, 1993). Although in recent years the endemic areas have tended to decrease as a result of adminis...

Attributing a great deal of attention to global and local knowledge, this paper is focused on law and society scholarship that has been published by Israelis, both Jewish and Arab-Palestinians. It attempts to unveil and to map some of the major issues that have characterised the scholarly debates and intellectual discourse, primarily critical questions on law and political power, the nation-sta...

Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism of DTG and assessed the potential for clinical drug-drug interactions. DTG is a substrate for the efflux transporters P-glycoprotein (Pgp) and huma...

Read all questions carefully. Answer all questions in the space provided. You may use scratch paper to do your work but only answers recorded on the test paper will be graded. Be as concise as possible. Note: the questions on this sample are all questions asked on past midterms, but this sample is longer than an hour test. Also, some of these questions turned out to be not great, so I probably ...

For many years, retrobulbar and peribulbar anesthesia were the standard for cataract surgery; however, many serious adverse effects have been reported (1, 2). With the introduction of modern phacoemulsification cataract surgery, topical anesthesia without retrobulbar or periocular injections has become a well-established, minimally invasive technique (3). The addition of intracameral lidocaine ...

Cytosolic sulfotransferases (SULTs) catalyze the sulfate conjugation of a myriad of endogenous and xenobiotic substrates. Among the 13 human SULTs, little is known regarding regulation of the SULT1C subfamily. We evaluated the effects of a panel of transcription factor activators on levels of SULT1C mRNA (1C2 and 1C3) and protein (1C2) in LS180 colorectal adenocarcinoma cells. Treatment with 3-...

Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively. How TLR4 coordinates the activation of these two pathways is unknown. Here we show that TLR4 activated these two signaling pathways sequentially in a process organ...