We developed an algorithm, Lever, that systematically maps metazoan DNA regulatory motifs or motif combinations to sets of genes. Lever assesses whether the motifs are enriched in cis-regulatory modules (CRMs), predicted by our PhylCRM algorithm, in the noncoding sequences surrounding the genes. Lever analysis allows unbiased inference of functional annotations to regulatory motifs and candidat...

It is well established that hypoxia causes excess accumulation of glutamate in developing neural tissues. This study aimed to elucidate the mechanism by which glutamate can cause retinal ganglion cell (RGC) death through the N-methyl-D-aspartate (NMDA) receptors (NR) in the developing retina. One-day-old Wistar rats were exposed to hypoxia for 2 hours and then killed at different time points. N...

Exogenous bone morphogenetic proteins (Bmp) are well known to induce ectopic bone formation, but the physiological effect of Bmp signaling on normal bone is not completely understood. By deleting the receptor Bmpr1a in osteoblast lineage cells with Dmp1-Cre, we observed a dramatic increase in trabecular bone mass in postnatal mice, which was due to a marked increase in osteoblast number that wa...

Objective. To evaluate primary care reform (PCR) in Barcelona during the year 2000 using 3 preventive practices: anti-smoking advice, blood pressure measurement, and flu vaccination. Any inequalities of gender, age, or social class in receiving these practices are also assessed. Design. Cross-sectional, descriptive, observational study. Setting. Barcelona Health Survey, primary health care, Spa...

http://bmj.com/cgi/content/full/330/7487/347 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/330/7487/347/DC1 "References w1 w29" References http://bmj.com/cgi/content/full/330/7487/347#BIBL This article cites 20 articles, 8 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/330/7487/347 You can re...

http://bmj.com/cgi/content/full/331/7512/347 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/331/7512/347/DC1 "Data used in the calculations" References http://bmj.com/cgi/content/full/331/7512/347#otherarticles 4 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/331/7512/347#BIBL This arti...

1 Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, Department of Metrology and Optoelectronics, ul. G. Narutowicza 11/12, 80-233 Gdansk, Poland, phone 48 58 347-14-87, fax 48 58 347-13-57, e-mail [email protected] 2 Gdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, Department of Metrology and Optoelectronics,...