Generalized Social Phobia (GSP) is a common anxiety disorder that produces clear social life disruptions. There is no consensus on the specific processes involved in its development, but the role of the hypothalamic-pituitary-adrenal (HPA) axis has been suggested. This study analyzed the effects of the cortisol response to the Trier Social Stress Test (TSST) on the memory retrieval of pictures ...

Because phosphodiesterase (PDE) expression and activity are controlled by cAMP, we investigated whether activating mutations of Gs alpha gene that occur in human GH-secreting adenomas are associated with increased PDE activity. We studied 10 adenomas with wild-type Gs alpha (gsp-) and 8 with mutant Gs alpha (gsp+). Although, in the absence of PDE inhibitors, intracellular cAMP levels were simil...

Sperm from different species have evolved distinctive motility structures, including tubulin-based flagella in mammals and major sperm protein (MSP)-based pseudopods in nematodes. Despite such divergence, we show that sperm-specific PP1 phosphatases, which are required for male fertility in mouse, function in multiple processes in the development and motility of Caenorhabditis elegans amoeboid ...

With increasing recognition of social phobia as a common and often debilitating disorder, interest is developing in its boundaries with other disorders such as avoidant personality disorder and temperamental constructs such as shyness. Such interest reflects the more general debate concerning Axis I disorders, personality disorders, and what is considered normal personality variance. This revie...

To improve the performance of a robust control, in presence of internal or external disturbance and uncertainties, to make a smooth tracking and elimination of high frequency disturbances especially in accurate systems with minimum power consumption an integration of robust optimal controller considered. Here, derivation and implementation of the proposed controller based on the combination of ...

1 Physics Department, M.V.Lomonosov Moscow State University 119992, Moscow, GSP-2, Leninskie Gory, Russian Federation [email protected]; [email protected] 2 Geology Department, M.V.Lomonosov Moscow State University 119992, Moscow, GSP-2, Leninskie Gory, Russian Federation [email protected]; [email protected] 3 Sternberg Astronomical Institute, M.V.Lomonosov Moscow State University 119992, Moscow, G...

Grain softness protein (GSP) is an important protein for overcoming milling and grain defenses in the innate immunity systems of cereals. The objective of this study was to evaluate and understand GSP sequences in selected wheat, rye and triticale. Using sequences for this gene from a sequence database, we performed clustering analysis to compare the sequences obtained from 3 germplasms wi...

In this paper, we present an approach, called PSP, for mining sequential patterns embedded in a database. Close to the problem of discovering association rules, mining sequential patterns requires handling time constraints. Originally introduced in 3], the issue is addressed by the GSP approach 10]. Our proposal resumes the general principles of GSP but it makes use of a diierent intermediary d...

Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated d...

Somatic GNAS point mutations, commonly known as gsp mutations, are involved in the pathogenesis of McCune-Albright syndrome (MAS) and have also been described in autonomous hormone-producing tumors, such as somatotropinoma, corticotrophoma, thyroid cancer, ovarian and testicular Leydig cell tumors, and primary macronodular adrenocortical hyperplasia (PMAH) (1-3). The involvement of gsp mutation...