نتایج جستجو برای: 3β-HSD

تعداد نتایج: 6625  

2013
Martin Krøyer Rasmussen Bo Ekstrand Galia Zamaratskaia

This review focuses on the expression and regulation of 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴ isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids and xenobiotics is more obscure. Based on currently available literature covering humans, rodents and pigs, this review provides an overview of ...

2016
Ze He Qin Sun Yuan-Jiao Liang Li Chen Yi-Feng Ge Shi-Feng Yun Bing Yao

This study was to investigate the effect of annexin A5 on testosterone secretion from primary rat Leydig cells and the underlying mechanisms. Isolated rat Leydig cells were treated with annexin A5. Testosterone production was detected by chemiluminescence assay. The protein and mRNA of Steroidogenic acute regulatory (StAR), P450scc, 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid d...

2015
Xian Li Yimin Jia Runsheng Li Zhiyuan Sun Xi Li Shiyan Sui Ruqian Zhao

BACKGROUND Hepatic 3β-hydroxysteroid dehydrogenase (3β-HSD) plays an important role in steroid inactivation and catabolism. Serum concentrations of steroid hormones differ significantly between breeds in pigs, however the molecular mechanism regulating hepatic 3β-HSD expression in different breeds of pigs is poorly understood. In the present study, we used preweaning purebred male Large White (...

2016
Toru Hanamura Tokiko Ito Toshiharu Kanai Kazuma Maeno Yasuyo Shimojo Takeshi Uehara Takashi Suzuki Shin‐ichi Hayashi Ken‐ichi Ito

Active sex steroids including estrogens and androgens are locally produced from circulating inactive steroids by various steroid-metabolizing enzymes, and play pivotal roles in the progression of hormone-dependent breast cancers. Human 3β-hydroxysteroid dehydrogenase type 1 (3β-HSD type 1) is a critical enzyme in the formation of all classes of active steroid hormones, and is also involved in t...

2010
Guo-Xin Hu Bing-Hai Zhao Yan-Hui Chu Hong-Yu Zhou Benson T. Akingbemi Zhi-Qiang Zheng Ren-Shan Ge

The objective of the present study was to investigate the effects of genistein and equol on 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) in human and rat testis microsomes. These enzymes (3β-HSD and 17β-HSD3), along with two others (cytochrome P450 side-chain cleavage enzyme and cytochrome P450 17α-hydroxylase/17-20 lyase), catalyze the reactions th...

M. Vessal, N. Fathi Z. Khoshdel

Background: Aqueous extract of winter cherry (Physalis alkekengi L; family of Solanaceae) fruits (WCF) has long been recommended for fertility control by herbalists in Iran. The effect of this extract on lowering serum progesterone levels has been reported previously. Objective: To study the effects of WCF extract on the activities of ovarian 3β-hydroxysteroid dehydrogenase (3β-HSD) responsible...

2004
JAN KOTWICA

The involvement of the arachidonic acid (AA) products, noradrenaline (NA) and LH in the stimulatory effect of progesterone on its own synthesis was tested using slices of CL from days 5-10 of the oestrous cycle of cow. Slices of CL (45-50 mg) were pre-incubated for 24 h, then the medium was replaced with fresh medium and 45 min later was supplemented with LH (100 ng/ml) as a positive control, o...

Journal: :Toxicology letters 2011
Leping Ye Binghai Zhao Guoxin Hu Yanhui Chu Ren-Shan Ge

Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it reduces serum testosterone level in rodents after exposure. However, the mechanism is unclear. The object of the present study is to investigate the effects of BPA on human and rat steroidogenic enzymes including P450 17α-hydroxylase/17,20-lyase (CYP17A1), 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxyster...

2016
Takashi Ando Tsutomu Nishiyama Itsuhiro Takizawa Fumio Ishizaki Yoshimichi Miyashiro Keisuke Takeda Noboru Hara Yoshihiko Tomita

Intratumoural dihydrotestosterone (DHT) synthesis could be an explanation for castration resistance in prostate cancer (PC). By using liquid chromatography-mass spectrometry, we evaluated the intratumoral DHT synthesis from 5α-androstane-3β,17β-diol (3β-diol), which is inactive androgen metabolized from DHT. 3β-diol had biochemical potential to be converted to DHT via three metabolic pathways a...

Journal: :Carcinogenesis 2011
Xunxian Liu Yun-Shang Piao Julia T Arnold

Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hyd...

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