hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. the high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. androgen effects on spatial memory are complex and contradictory. some evidence suggests a positive correlation between androgens and spatial memo...

Hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. The high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. Androgen effects on spatial memory are complex and contradictory. Some evidence suggests a positive correlation between androgens and spatial memo...

Hippocampus is essentially involved in learning and memory processes, and is known to be a target for androgen actions. The high density of the androgen receptors in hippocampus shows that there must be some relationship between androgens and memory. Androgen effects on spatial memory are complex and contradictory. Some evidence suggests a positive correlation between androgens and spatial memo...

The biocatalyzed conversion of hyocholic acid (3α,6α,7α-trihydroxy-5β-cholan-24-oic acid) into ω-muricholic (3α,6α,7β-trihydroxy-5β-cholan-24-oic has been obtained exploiting a small library 7α- and 7β-HSDHs (hydroxysteroid dehydrogenases). process optimized performed avoiding the isolation 7-oxo intermediate using appropriate coupled enzymes for in situ cofactor regeneration. Moreover, reducti...

BACKGROUND Eicosapentaenoic acid-derived prostaglandin (PG) E3, PGF(3α), and thromboxane (TX) B3 are bioactive lipid mediators which have anti-cancer and anti-inflammatory effects. To exert their effects, PGE3, PGF(3α), and TXB3 must be released to the extracellular space from cells, but the release mechanism has been unclear. We therefore investigated the contribution of ATP-binding cassette t...

Background and aim: Macrophage inflammatory protein 3α (MIP-3α) is a recently described lymphocyte directed C-C chemokine expressed predominately at extralymphoid sites, including the intestine. The aim of this study was to determine whether colonic epithelial cells produce MIP-3α and whether its expression is upregulated in inflammatory bowel disease. Methods and results: We found that interle...

This study was aimed to investigate the roles of serum macrophage inflammatory protein-3α (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) prognosis.The serum levels of MIP-3α and cystatin A in 140 primary NPC patients without distant metastasis were detected by enzyme-linked immunosorbent assay before and after treatment. The results were compared with those in 100 healthy controls. T...

abstract background and aim: survivin is a new member of inhibitor of apoptosis protein family (iap) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. thyroid carcinoma is the most common endocrine malignancy. considering the h...

We found that 3α-hydroxysteroid dehydrogenase (3α-HSD) from Pseudomonas sp. B-0831 can catalyze the carbonyl reduction of non-steroid substrates, such as metyrapone and p-nitrobenzaldehyde, in addition to the activity of 3α-hydroxysteroid dehydrogenase. The results of an inhibition study in metyrapone reduction by androsterone and cholic acid indicated that metyrapone bound to the same catalyti...

The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β-subunit. While HIF-1 and HIF-2 function as master regulators of the transcriptional response to hypoxia, much less is known about HIF-3. The HIF-3α gene gives rise to multiple HIF-3α variants due to the utilization of ...