Abstract A new energetic cocrystal of 2,4,6,8,10,12‐hexanitrohexaazaisowurtzitane (CL‐20) and 1,4‐dinitropyrazole (1,4‐DNP) with a 1 : molar ratio was prepared by slow solvent evaporation. This belongs to monoclinic system P 2 / c space group formed mainly the CH−O, CH−N, NO −π interactions through analyzing structures interactions. CL‐20/1,4‐DNP has melting point 132 °C decomposition temperatu...

In the present work, the sensitivity to the moisture (hygroscopisity) is studied for 3,4-dinitropyrazole (DNP) as a famous energetic molecule. All of the DNP-H2O complex systems (1-3) as well as individual molecules were optimized and bond lengths, bond angles, dihedral angles, charge transfer and stability via NBO analysis, corrected interaction energies with ZPE + BSSE and hydrogen bonds anal...

Objective(s): It is difficult to investigate the whole-body distribution of an orally administered drug by means of positron emission tomography (PET), owing to the short physical half-life of radionuclides, especially when 11C-labeled compounds are tested. Therefore, we aimed to examine the whole-body distribution of donepezil (DNP) as an acetylcholinesterase inhibitor by means of 11C-DNP PET ...

Rabbit anti-2,4-dintrophenyl (DNP) antibodies or their F(ab')2 fragments were chemically cross-linked to the anti-mouse Fc gamma R monoclonal antibody 2.4G2 or to its Fab fragment. P388D1 cells were incubated with heteroaggregates between 2.4G2 and anti-DNP (anti-Fc gamma R X anti-DNP) and washed. The resulting cells lysed 2,4,6-trinitrophenyl chicken erythrocytes (TNP CRBC) in a hapten-specifi...

objective(s): it is difficult to investigate the whole-body distribution of an orally administered drug by means of positron emission tomography (pet), owing to the short physical half-life of radionuclides, especially when 11c-labeled compounds are tested. therefore, we aimed to examine the whole-body distribution of donepezil (dnp) as an acetylcholinesterase inhibitor by means of 11c-dnp pet ...

Two-color whole-mount in situ hybridization is a powerful technique for comparing the spatial expression patterns of two genes in developing embryos or within a given adult tissue. Many current procedures use two genespecific antisense RNA probes, each incorporating a different chemical moiety that is recognized by a specific antibody. Typically, the first gene-specific RNA probe is labeled wit...

Cells binding DNP groups conjugated to fluoresceinated mouse gamma globulin ((F)DNP-MGG) were isolated from spleens of unprimed mice using a fluorescence-activated cell sorter (FACS). The isolated cells were specifically enriched at least 100-fold for anti-DNP precursor activity in an adoptive transfer assay as compared to unfractionated spleen. The fraction depleted of binding cells, although ...