Synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives from aldehydes, 1,3-dicarbonyl derivatives and urea or thiourea using granite and quartz as new, natural and reusable catalysts. Some of the 3,4-dihydropyrimidin-2(1H)-thione derivatives were used to prepare new heterocyclic compounds. The antimicrobial activity of selected examples of the synthesized ...

An efficient protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via multi-component coupling reaction of aromatic aldehydes, β-ketoester and urea or thiourea under solvent-free conditions using Silica Supported Barium Chloride as a catalyst is described. All prepared compounds with melting points, IR,1H NMR and 13C NMR were identified. High yields, mild conditi...

   This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provi...

A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via one-pot three-component Biginelli condensation of arylaldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas anefficient, readily and inexpensive catalyst under solvent-free conditions have been studied. Thisprotocol ha...

We report herein the synthesis of a new biologically active 3,4-dihydropyrimidin-2(1H)-thione derivative (4) from 9-phenanthrenecarboxaldehyde, thiourea, and methyl acetoacetate by Biginelli reaction. The structure synthesized compound was investigated NMR spectroscopy, mass spectrometry, elemental analysis. Moreover, to gain insight into conformation crystal packing, novel dihydropyrimidine al...

Chem. Abstr. Serv. Reg. No.: 60-56-0 Deleted CAS Reg. Nos: 4708-61-6; 85916-84-3 Chem. Abstr. Name: 1,3-Dihydro-1-methyl-2H-imidazole-2-thione IUPAC Systematic Names: 1-Methylimidazole-2-thiol; 1-methyl-4-imidazoline-2thione Synonyms: 2-Mercapto-1-methyl-1H-imidazole; 2-mercapto-1-methylimidazole; mercazolylum; 1-methyl-1,3-dihydroimidazole-2-thione; N-methylimidazolethiol; 1-methyl-2-imidazole...

Two new molecular structures, namely 1,3-bis(trimethylsilyl)-1H-benzimidazole-2(3H)-thione, C13H22N2SSi2, (2), and 1-trimethylsilyl-1H-benzimidazole-2(3H)-thione, C10H14N2SSi, (3), are reported. Both systems were derived from 1H-benzimidazole-2(3H)-thione. Noncovalent C-H···π interactions between the centroid of the benzmidazole system and the SiMe3 groups form helicoidal arrangements in (2). D...

the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...